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Author (up) Anbalagan, M.; Dauchy, R.; Xiang, S.; Robling, A.; Blask, D.; Rowan, B.; Hill, S. url  doi
openurl 
  Title SAT-337 Disruption Of The Circadian Melatonin Signal By Dim Light At Night Promotes Bone-lytic Breast Cancer Metastases Type Journal Article
  Year 2019 Publication Journal of the Endocrine Society Abbreviated Journal  
  Volume 3 Issue Supplement_1 Pages  
  Keywords Animals  
  Abstract Breast cancer metastasis to bone is a major source of morbidity and mortality in women with advanced metastatic breast cancer. Morbidity from metastasis to bone is compounded by the fact that they cannot be surgically removed and can only be treated with chemotherapy and/or radiation therapy. Thus, there is critical need to develop new treatment strategies that kill bone metastatic tumors and reduce osteolytic lesions to improve patient quality of life and extend patient survival. Circadian rhythms are daily cycles of ~24 h that control many if not most physiologic processes and their disruption by exposure to light at night (LAN) or jet lag has been shown to be strongly associated with the development of cancer, particularly breast cancer. We have found that disruption of the anti-cancer circadian hormone melatonin (MLT) by light at night can significantly enhance the metastatic potential in breast cancer cells. Our work supports the report of the International Agency for Research on Cancer that shift work is a “probable human carcinogen” and highlights the association between exposure to light at night and invasive breast cancer. We recently reported that human breast tumor xenografts grown in athymic nude female rats housed in a photoperiod of 12h light at day: 12h dim light at night (dLAN, 0.2 lux – blocks the nighttime circadian MLT signal), display resistance to doxorubicin (Dox). More importantly, tumor growth and drug resistance could be blocked by the administration of Dox in circadian alignment with nocturnal MLT during dLAN. Our recent preliminary studies show that poorly invasive ERα positive MCF-7 breast cancer cells, when injected into the tibia (to mimic bone metastatic disease) of Foxn1nu athymic nude mice (which produce a strong circadian nighttime melatonin signal) housed in a dLAN photoperiod (suppressed nocturnal MLT production) developed full blown breast cancer tumors in bone (P<0.05) that are highly osteolytic (P<0.05). Moreover, patients with metastatic breast cancer are routinely treated with doxorubicin, which itself can promote bone damage. Our studies demonstrate that MLT slows the growth of metastatic breast cancer in bone but that the chrono-therapeutic use of doxorubicin in circadian alignment with melatonin in Foxn1nu mice with tibial breast tumors, reduced tumor growth in bone, reduced bone erosion, and promoted the formation of new bone. Successful use of this chronotherapeutic use of Dox and MLT in clinical trials increasing efficacy in preventing or suppressing breast cancer metastasis to bone while decreasing toxic side effects of doxorubicin would provide a revolutionary advancement in the treatment of bone metastatic breast cancer and decrease the morbidity and mortality associated with breast cancer metastasis to bone.  
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  ISSN 2472-1972 ISBN Medium  
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  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 2433  
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Author (up) Barducci, A.; Marcoionni, P.; Pippi, I.; Poggesi, M. url  doi
openurl 
  Title Effects of light pollution revealed during a nocturnal aerial survey by two hyperspectral imagers Type Journal Article
  Year 2003 Publication Applied Optics Abbreviated Journal Appl. Opt.  
  Volume 42 Issue 21 Pages 4349  
  Keywords Remote Sensing  
  Abstract A remote-sensing campaign was performed in September 2001 at nighttime under clear-sky conditions before moonrise to assess the level of light pollution of urban and industrial origin. Two hyperspectral sensors, namely, the Multispectral Infrared and Visible Imaging Spectrometer and the Visible Infrared Scanner-200, which provide spectral coverage from the visible to the thermal infrared, were flown over the Tuscany coast (Italy) on board a Casa 212 airplane. The acquired images were processed to produce radiometrically calibrated data, which were then analyzed and compared with ground-based spectral measurements. Calibrated data acquired at high spectral resolution (∼2.5 nm) showed a maximum scene brightness almost of the same order of magnitude as that observed during similar daytime measurements, whereas their average luminosity was 3 orders of magnitude lower. The measurement analysis confirmed that artificial illumination hinders astronomical observations and produces noticeable effects even at great distances from the sources of the illumination.  
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  ISSN 0003-6935 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 2438  
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Author (up) Barros, R.; Medrano, F.; Norambuena, H.V.; Peredo, R.; Silva, R.; de Groote, F.; Schmitt, F. url  doi
openurl 
  Title Breeding Phenology, Distribution and Conservation Status of Markham's Storm-Petrel Oceanodroma markhami in the Atacama Desert Type Journal Article
  Year 2019 Publication Ardea Abbreviated Journal Ardea  
  Volume 107 Issue 1 Pages 75  
  Keywords Animals  
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  Series Volume Series Issue Edition  
  ISSN 0373-2266 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 2434  
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Author (up) Bedrosian, T.A.; Nelson, R.J. url  doi
openurl 
  Title Timing of light exposure affects mood and brain circuits Type Journal Article
  Year 2017 Publication Translational Psychiatry Abbreviated Journal Transl Psychiatry  
  Volume 7 Issue 1 Pages e1017  
  Keywords Review; Human Health  
  Abstract Temporal organization of physiology is critical for human health. In the past, humans experienced predictable periods of daily light and dark driven by the solar day, which allowed for entrainment of intrinsic circadian rhythms to the environmental light-dark cycles. Since the adoption of electric light, however, pervasive exposure to nighttime lighting has blurred the boundaries of day and night, making it more difficult to synchronize biological processes. Many systems are under circadian control, including sleep-wake behavior, hormone secretion, cellular function and gene expression. Circadian disruption by nighttime light perturbs those processes and is associated with increasing incidence of certain cancers, metabolic dysfunction and mood disorders. This review focuses on the role of artificial light at night in mood regulation, including mechanisms through which aberrant light exposure affects the brain. Converging evidence suggests that circadian disruption alters the function of brain regions involved in emotion and mood regulation. This occurs through direct neural input from the clock or indirect effects, including altered neuroplasticity, neurotransmission and clock gene expression. Recently, the aberrant light exposure has been recognized for its health effects. This review summarizes the evidence linking aberrant light exposure to mood.  
  Address Department of Neuroscience, Behavioral Neuroendocrinology Group, The Ohio State University Wexner Medical Center, Columbus, OH, USA  
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  Language English Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN 2158-3188 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28140399; PMCID:PMC5299389 Approved no  
  Call Number GFZ @ kyba @ Serial 2446  
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Author (up) Bowlby, G.M.S. url  doi
openurl 
  Title Some Preliminary Investigations into the Effects of Light on Broilers Type Journal Article
  Year 1957 Publication World's Poultry Science Journal Abbreviated Journal Worlds Poult. Sci. J.  
  Volume 13 Issue 03 Pages 214-216  
  Keywords Animals  
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  Series Volume Series Issue Edition  
  ISSN 0043-9339 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 2426  
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