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Author Dauchy, R.T.; Xiang, S.; Mao, L.; Brimer, S.; Wren, M.A.; Yuan, L.; Anbalagan, M.; Hauch, A.; Frasch, T.; Rowan, B.G.; Blask, D.E.; Hill, S.M. url  doi
openurl 
  Title Circadian and melatonin disruption by exposure to light at night drives intrinsic resistance to tamoxifen therapy in breast cancer Type Journal Article
  Year 2014 Publication Cancer Research Abbreviated Journal Cancer Res  
  Volume 74 Issue 15 Pages 4099-4110  
  Keywords *Cancer; breast cancer; melatonin; endocrinology; tamoxifen; *Circadian Rhythm; circadian disruption; human health; epidemiology  
  Abstract Resistance to endocrine therapy is a major impediment to successful treatment of breast cancer. Preclinical and clinical evidence links resistance to antiestrogen drugs in breast cancer cells with the overexpression and/or activation of various pro-oncogenic tyrosine kinases. Disruption of circadian rhythms by night shift work or disturbed sleep-wake cycles may lead to an increased risk of breast cancer and other diseases. Moreover, light exposure at night (LEN) suppresses the nocturnal production of melatonin that inhibits breast cancer growth. In this study, we used a rat model of estrogen receptor (ERalpha(+)) MCF-7 tumor xenografts to demonstrate how altering light/dark cycles with dim LEN (dLEN) speed the development of breast tumors, increasing their metabolism and growth and conferring an intrinsic resistance to tamoxifen therapy. These characteristics were not observed in animals in which the circadian melatonin rhythm was not disrupted, or in animals subjected to dLEN if they received nocturnal melatonin replacement. Strikingly, our results also showed that melatonin acted both as a tumor metabolic inhibitor and a circadian-regulated kinase inhibitor to reestablish the sensitivity of breast tumors to tamoxifen and tumor regression. Together, our findings show how dLEN-mediated disturbances in nocturnal melatonin production can render tumors insensitive to tamoxifen. Cancer Res; 74(15); 4099-110. (c)2014 AACR.  
  Address Departments of Structural and Cellular Biology and Tulane Cancer Center and Louisiana Cancer Research Consortium; Tulane Circadian Cancer Biology Group; and  
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  ISSN 0008-5472 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:25062775; PMCID:PMC4119539 Approved (up) no  
  Call Number IDA @ john @ Serial 355  
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Author Figueiro, M.G.; Wood, B.; Plitnick, B.; Rea, M.S. url  doi
openurl 
  Title The impact of watching television on evening melatonin levels: Impact of watching television on evening melatonin Type Journal Article
  Year 2013 Publication Journal of the Society for Information Display Abbreviated Journal Jnl Soc Info Display  
  Volume 21 Issue 10 Pages 417-421  
  Keywords Human Health; television; correlated color temperature; sleep; melatonin levels; blue light; circadian disruption  
  Abstract Self-luminous electronic devices emit optical radiation at short wavelengths, close to the peak sensitivity of melatonin suppression. The present paper investigated if light from a 178-cm (70 in.) television suppressed melatonin. Results showed that light from televisions does not impact melatonin levels in the evening.  
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  Series Volume Series Issue Edition  
  ISSN 1071-0922 ISBN Medium  
  Area Expedition Conference  
  Notes Approved (up) no  
  Call Number LoNNe @ christopher.kyba @ Serial 498  
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Author Czeisler, C.A. url  doi
openurl 
  Title Perspective: casting light on sleep deficiency Type Journal Article
  Year 2013 Publication Nature Abbreviated Journal Nature  
  Volume 497 Issue 7450 Pages S13  
  Keywords Human Health; Circadian Rhythm/physiology/radiation effects; Electricity/adverse effects; Humans; Jet Lag Syndrome/etiology/physiopathology/therapy; Lighting/*adverse effects; Melatonin/metabolism/secretion; Phototherapy; Sleep Deprivation/epidemiology/*etiology/*physiopathology/therapy; Suprachiasmatic Nucleus/physiology/radiation effects  
  Abstract  
  Address Division of Sleep Medicine, Harvard Medical School, and Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital, in Boston, Massachusetts, USA. charles_czeisler@hms.harvard.edu  
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  Series Volume Series Issue Edition  
  ISSN 0028-0836 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23698501 Approved (up) no  
  Call Number LoNNe @ christopher.kyba @ Serial 499  
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Author Eisenstein, M. url  doi
openurl 
  Title Chronobiology: stepping out of time Type Journal Article
  Year 2013 Publication Nature Abbreviated Journal Nature  
  Volume 497 Issue 7450 Pages S10-2  
  Keywords Human Health; Animals; Benzofurans/therapeutic use; CLOCK Proteins/genetics/metabolism; Circadian Rhythm/genetics/*physiology; Cyclopropanes/therapeutic use; Efficiency/physiology; Humans; Melatonin/agonists/metabolism; Obesity/metabolism; Sleep/genetics/*physiology; Suprachiasmatic Nucleus/metabolism  
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  ISSN 0028-0836 ISBN Medium  
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  Notes PMID:23698500 Approved (up) no  
  Call Number LoNNe @ christopher.kyba @ Serial 500  
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Author Kantermann, T. url  doi
openurl 
  Title Circadian biology: sleep-styles shaped by light-styles Type Journal Article
  Year 2013 Publication Current Biology : CB Abbreviated Journal Curr Biol  
  Volume 23 Issue 16 Pages R689-90  
  Keywords Human Health; Circadian Clocks/*radiation effects; Female; Humans; *Lighting; Male; *Photoperiod; *Sunlight  
  Abstract Light and darkness are the main time cues synchronising all biological clocks to the external environment. This little understood evolutionary phenomenon is called circadian entrainment. A new study illuminates our understanding of how modern light- and lifestyles compromise circadian entrainment and impact our biological clocks.  
  Address Chronobiology – Centre for Behaviour and Neurosciences, University of Groningen, Nijenborgh 7, 9747 AG Groningen, The Netherlands. thomas@kantermann.de  
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  ISSN 0960-9822 ISBN Medium  
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  Notes PMID:23968925 Approved (up) no  
  Call Number LoNNe @ christopher.kyba @ Serial 501  
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