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Author |
Skeldon, A.C.; Phillips, A.J.K.; Dijk, D.-J. |
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Title |
The effects of self-selected light-dark cycles and social constraints on human sleep and circadian timing: a modeling approach |
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Journal Article |
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Year |
2017 |
Publication |
Scientific Reports |
Abbreviated Journal |
Sci Rep |
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Volume |
7 |
Issue |
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Pages  |
45158 |
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Keywords |
human health, lighting |
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Abstract |
Why do we go to sleep late and struggle to wake up on time? Historically, light-dark cycles were dictated by the solar day, but now humans can extend light exposure by switching on artificial lights. We use a mathematical model incorporating effects of light, circadian rhythmicity and sleep homeostasis to provide a quantitative theoretical framework to understand effects of modern patterns of light consumption on the human circadian system. The model shows that without artificial light humans wakeup at dawn. Artificial light delays circadian rhythmicity and preferred sleep timing and compromises synchronisation to the solar day when wake-times are not enforced. When wake-times are enforced by social constraints, such as work or school, artificial light induces a mismatch between sleep timing and circadian rhythmicity ('social jet-lag'). The model implies that developmental changes in sleep homeostasis and circadian amplitude make adolescents particularly sensitive to effects of light consumption. The model predicts that ameliorating social jet-lag is more effectively achieved by reducing evening light consumption than by delaying social constraints, particularly in individuals with slow circadian clocks or when imposed wake-times occur after sunrise. These theory-informed predictions may aid design of interventions to prevent and treat circadian rhythm-sleep disorders and social jet-lag. |
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University of Surrey, Surrey Sleep Research Centre, Guildford, GU2 7XP, UK |
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2045-2322 |
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PMID:28345624 |
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no |
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Call Number |
SU @ spitschan @ |
Serial |
1638 |
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Author |
Walker, W.H. 2nd; Borniger, J.C.; Gaudier-Diaz, M.M.; Hecmarie Melendez-Fernandez, O.; Pascoe, J.L.; Courtney DeVries, A.; Nelson, R.J. |
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Title |
Acute exposure to low-level light at night is sufficient to induce neurological changes and depressive-like behavior |
Type |
Journal Article |
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Year |
2019 |
Publication |
Molecular Psychiatry |
Abbreviated Journal |
Mol Psychiatry |
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Volume |
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Issue |
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Pages |
s41380-019-0430-4 |
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Keywords |
Human health; physiology; brain |
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Abstract |
The advent and wide-spread adoption of electric lighting over the past century has profoundly affected the circadian organization of physiology and behavior for many individuals in industrialized nations; electric lighting in homes, work environments, and public areas have extended daytime activities into the evening, thus, increasing night-time exposure to light. Although initially assumed to be innocuous, chronic exposure to light at night (LAN) is now associated with increased incidence of cancer, metabolic disorders, and affective problems in humans. However, little is known about potential acute effects of LAN. To determine whether acute exposure to low-level LAN alters brain function, adult male, and female mice were housed in either light days and dark nights (LD; 14 h of 150 lux:10 h of 0 lux) or light days and low level light at night (LAN; 14 h of 150 lux:10 h of 5 lux). Mice exposed to LAN on three consecutive nights increased depressive-like responses compared to mice housed in dark nights. In addition, female mice exposed to LAN increased central tendency in the open field. LAN was associated with reduced hippocampal vascular endothelial growth factor-A (VEGF-A) in both male and female mice, as well as increased VEGFR1 and interleukin-1beta mRNA expression in females, and reduced brain derived neurotrophic factor mRNA in males. Further, LAN significantly altered circadian rhythms (activity and temperature) and circadian gene expression in female and male mice, respectively. Altogether, this study demonstrates that acute exposure to LAN alters brain physiology and can be detrimental to well-being in otherwise healthy individuals. |
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Department of Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, 26506, USA |
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Nature |
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English |
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1359-4184 |
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PMID:31138889 |
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no |
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Call Number |
IDA @ john @ |
Serial |
2509 |
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Author |
Walker, W.H. 2nd; Borniger, J.C.; Gaudier-Diaz, M.M.; Hecmarie Melendez-Fernandez, O.; Pascoe, J.L.; Courtney DeVries, A.; Nelson, R.J. |
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Title |
Acute exposure to low-level light at night is sufficient to induce neurological changes and depressive-like behavior |
Type |
Journal Article |
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Year |
2019 |
Publication |
Molecular Psychiatry |
Abbreviated Journal |
Mol Psychiatry |
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Volume |
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Issue |
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Pages |
s41380 |
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Keywords |
Animals; mouse models; mood disorders; Human Health |
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Abstract |
The advent and wide-spread adoption of electric lighting over the past century has profoundly affected the circadian organization of physiology and behavior for many individuals in industrialized nations; electric lighting in homes, work environments, and public areas have extended daytime activities into the evening, thus, increasing night-time exposure to light. Although initially assumed to be innocuous, chronic exposure to light at night (LAN) is now associated with increased incidence of cancer, metabolic disorders, and affective problems in humans. However, little is known about potential acute effects of LAN. To determine whether acute exposure to low-level LAN alters brain function, adult male, and female mice were housed in either light days and dark nights (LD; 14 h of 150 lux:10 h of 0 lux) or light days and low level light at night (LAN; 14 h of 150 lux:10 h of 5 lux). Mice exposed to LAN on three consecutive nights increased depressive-like responses compared to mice housed in dark nights. In addition, female mice exposed to LAN increased central tendency in the open field. LAN was associated with reduced hippocampal vascular endothelial growth factor-A (VEGF-A) in both male and female mice, as well as increased VEGFR1 and interleukin-1beta mRNA expression in females, and reduced brain derived neurotrophic factor mRNA in males. Further, LAN significantly altered circadian rhythms (activity and temperature) and circadian gene expression in female and male mice, respectively. Altogether, this study demonstrates that acute exposure to LAN alters brain physiology and can be detrimental to well-being in otherwise healthy individuals. |
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Department of Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, 26506, USA |
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English |
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1359-4184 |
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PMID:31138889; PMCID:PMC6881534 |
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no |
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Call Number |
GFZ @ kyba @ |
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2768 |
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Author |
Kang, S.-G.; Yoon, H.-K.; Cho, C.-H.; Kwon, S.; Kang, J.; Park, Y.-M.; Lee, E.; Kim, L.; Lee, H.-J. |
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Title |
Decrease in fMRI brain activation during working memory performed after sleeping under 10 lux light |
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Journal Article |
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Year |
2016 |
Publication |
Scientific Reports |
Abbreviated Journal |
Sci Rep |
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Volume |
6 |
Issue |
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Pages |
36731 |
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Keywords |
Human Health |
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Abstract |
The aim of this study was to investigate the effect of exposure to dim light at night (dLAN) when sleeping on functional brain activation during a working-memory tasks. We conducted the brain functional magnetic resonance imaging (fMRI) analysis on 20 healthy male subjects. All participants slept in a polysomnography laboratory without light exposure on the first and second nights and under a dim-light condition of either 5 or 10 lux on the third night. The fMRI scanning was conducted during n-back tasks after second and third nights. Statistical parametric maps revealed less activation in the right inferior frontal gyrus (IFG) after exposure to 10-lux light. The brain activity in the right and left IFG areas decreased more during the 2-back task than during the 1- or 0-back task in the 10-lux group. The exposure to 5-lux light had no significant effect on brain activities. The exposure to dLAN might influence the brain function which is related to the cognition. |
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Department of Psychiatry, Korea University College of Medicine, Seoul, Korea |
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2045-2322 |
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Notes |
PMID:27827445; PMCID:PMC5101482 |
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no |
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Call Number |
LoNNe @ kyba @ |
Serial |
1560 |
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Author |
Pacheco-Tucuch, F.S.; Ramirez-Sierra, M.J.; Gourbiere, S.; Dumonteil, E. |
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Title |
Public street lights increase house infestation by the Chagas disease vector Triatoma dimidiata |
Type |
Journal Article |
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Year |
2012 |
Publication |
PloS one |
Abbreviated Journal |
PLoS One |
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Volume |
7 |
Issue |
4 |
Pages |
e36207 |
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Keywords |
Animals; Human Health |
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Abstract |
Triatoma dimidiata is one of the primary vectors of Chagas disease. We previously documented the spatio-temporal infestation of houses by this species in the Yucatan peninsula, Mexico, and found that non-domiciliated triatomines were specifically attracted to houses. However, the factors mediating this attraction remained unclear. Artificial light has been known for a long time to attract many insect species, and therefore may contribute to the spread of different vector-borne diseases. Also, based on the collection of different species of triatomines with light traps, several authors have suggested that light might attract triatomines to houses, but the role of artificial light in house infestation has never been clearly demonstrated and quantified. Here we performed a spatial analysis of house infestation pattern by T. dimidiata in relation to the distribution of artificial light sources in three different villages from the Yucatan peninsula, Mexico. In all three villages, infested houses were significantly closer to public street light sources than non-infested houses (18.0 +/- 0.6 vs 22.6 +/- 0.4 m), and street lights rather than domestic lights were associated with house infestation. Accordingly, houses closer to a public street lights were 1.64 times more likely to be infested than houses further away (OR, CI95% 1.23-2.18). Behavioral experiments using a dual-choice chamber further confirmed that adult male and females were attracted to white light during their nocturnal activity. Attraction was also dependent on light color and decreased with increasing wavelength. While public lighting is usually associated with increased development, these data clearly show that it also directly contributes to house infestation by non-domiciliated T. dimidiata. |
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Laboratorio de Parasitologia, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autonoma de Yucatan, Merida, Yucatan, Mexico |
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English |
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ISSN |
1932-6203 |
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PMID:22558384; PMCID:PMC3338588 |
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no |
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Call Number |
LoNNe @ kyba @ |
Serial |
1489 |
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