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Author |
Zubidat, A.E.; Fares, B.; Fares, F.; Haim, A. |
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Title |
Artificial Light at Night of Different Spectral Compositions Differentially Affects Tumor Growth in Mice: Interaction With Melatonin and Epigenetic Pathways |
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Journal Article |
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Year |
2018 |
Publication |
Cancer Control : Journal of the Moffitt Cancer Center |
Abbreviated Journal |
Cancer Control |
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Volume |
25 |
Issue |
1 |
Pages  |
1073274818812908 |
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Keywords |
Human Health; 6-Smt; Cfl; EE-halogen; GDM-levels; body mass; carbon; corticosterone; cosinor analysis; light at night; yellow-LED |
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Abstract |
Lighting technology is rapidly advancing toward shorter wavelength illuminations that offer energy-efficient properties. Along with this advantage, the increased use of such illuminations also poses some health challenges, particularly breast cancer progression. Here, we evaluated the effects of artificial light at night (ALAN) of 4 different spectral compositions (500-595 nm) at 350 Lux on melatonin suppression by measuring its urine metabolite 6-sulfatoxymelatonin, global DNA methylation, tumor growth, metastases formation, and urinary corticosterone levels in 4T1 breast cancer cell-inoculated female BALB/c mice. The results revealed an inverse dose-dependent relationship between wavelength and melatonin suppression. Short wavelength increased tumor growth, promoted lung metastases formation, and advanced DNA hypomethylation, while long wavelength lessened these effects. Melatonin treatment counteracted these effects and resulted in reduced cancer burden. The wavelength suppression threshold for melatonin-induced tumor growth was 500 nm. These results suggest that short wavelength increases cancer burden by inducing aberrant DNA methylation mediated by the suppression of melatonin. Additionally, melatonin suppression and global DNA methylation are suggested as promising biomarkers for early diagnosis and therapy of breast cancer. Finally, ALAN may manifest other physiological responses such as stress responses that may challenge the survival fitness of the animal under natural environments. |
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1 The Israeli Center for Interdisciplinary Research in Chronobiology, University of Haifa, Haifa, Israel |
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SAGE |
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English |
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English |
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ISSN |
1073-2748 |
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PMID:30477310; PMCID:PMC6259078 |
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no |
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Call Number |
IDA @ john @ |
Serial |
2143 |
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Author |
Li, Y.; Cheng, S.; Li, L.; Zhao, Y.; Shen, W.; Sun, X. |
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Title |
Light-exposure at night impairs mouse ovary development via cell apoptosis and DNA damage |
Type |
Journal Article |
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Year |
2019 |
Publication |
Bioscience Reports |
Abbreviated Journal |
Biosci Rep |
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Volume |
39 |
Issue |
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Pages |
BSR20181464 |
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Keywords |
Human Health; Animals; mouse models; ovaries |
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Abstract |
The alternation of light and dark rhythm causes a series of physiological, biochemical and metabolic changes in animals, which also alters the growth and development of animals, and feeding, migration, reproduction and other behavioral activities. In recent years, many studies have reported the effects of long-term (more than 6 weeks) illumination on ovarian growth and development. In this study, we observed the damage, repair and apoptosis of ovarian DNA in a short period of illumination. The results showed that, in short time (less than 2 weeks) illumination conditions, the 24 hrs-light treatment caused the reduction of total ovarian follicle number and downregulation of circadian clock related genes. Furthermore, the changed levels of serum sex hormones were also detected after 24 hrs-light exposure, of which the concentrations of LH (luteinizing hormone), FSH (follicle-stimulating hormone) and E2 (estradiol) were increased, but the concentration of PROG (progesterone) was decreased. Moreover, 24 hrs-light exposure increased the expression of DNA damage and repair related genes, the number of TUNEL and RAD51 positive cells. These results indicated that 24 hrs-light exposure for 4 days, 8days and 12 days increased DNA damage and cell apoptosis, thereby affecting the development of ovary. |
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Qingdao agricultural university, Qingdao, China; xfsun@qau.edu.cn |
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Portland Press |
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English |
Summary Language |
English |
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0144-8463 |
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PMID:30962269 |
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Call Number |
GFZ @ kyba @ |
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2293 |
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Author |
Kernbach, M.E.; Newhouse, D.J.; Miller, J.M.; Hall, R.J.; Gibbons, J.; Oberstaller, J.; Selechnik, D.; Jiang, R.H.Y.; Unnasch, T.R.; Balakrishnan, C.N.; Martin, L.B. |
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Title |
Light pollution increases West Nile virus competence of a ubiquitous passerine reservoir species |
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Journal Article |
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Year |
2019 |
Publication |
Proceedings. Biological Sciences |
Abbreviated Journal |
Proc Biol Sci |
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Volume |
286 |
Issue |
1907 |
Pages |
20191051 |
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Keywords |
Animals; Human Health; anthropogenic; ecoimmunology; host competence; light pollution; reservoir host |
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Abstract |
Among the many anthropogenic changes that impact humans and wildlife, one of the most pervasive but least understood is light pollution. Although detrimental physiological and behavioural effects resulting from exposure to light at night are widely appreciated, the impacts of light pollution on infectious disease risk have not been studied. Here, we demonstrate that artificial light at night (ALAN) extends the infectious-to-vector period of the house sparrow (Passer domesticus), an urban-dwelling avian reservoir host of West Nile virus (WNV). Sparrows exposed to ALAN maintained transmissible viral titres for 2 days longer than controls but did not experience greater WNV-induced mortality during this window. Transcriptionally, ALAN altered the expression of gene regulatory networks including key hubs (OASL, PLBD1 and TRAP1) and effector genes known to affect WNV dissemination (SOCS). Despite mounting anti-viral immune responses earlier, transcriptomic signatures indicated that ALAN-exposed individuals probably experienced pathogen-induced damage and immunopathology, potentially due to evasion of immune effectors. A simple mathematical modelling exercise indicated that ALAN-induced increases of host infectious-to-vector period could increase WNV outbreak potential by approximately 41%. ALAN probably affects other host and vector traits relevant to transmission, and additional research is needed to advise the management of zoonotic diseases in light-polluted areas. |
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Center for Global Health Infectious Disease Research, University of South Florida, Tampa, FL 33620, USA |
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English |
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0962-8452 |
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PMID:31337318; PMCID:PMC6661335 |
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no |
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Call Number |
GFZ @ kyba @ |
Serial |
2611 |
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Author |
Wahl, S.; Engelhardt, M.; Schaupp, P.; Lappe, C.; Ivanov, I.V. |
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Title |
The inner clock – blue light sets the human rhythm |
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Journal Article |
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Year |
2019 |
Publication |
Journal of Biophotonics |
Abbreviated Journal |
J Biophotonics |
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Volume |
12 |
Issue |
12 |
Pages |
e201900102 |
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Keywords |
Human Health; blue light; circadian rhythm; melanopsin; melatonin; visible light |
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Visible light synchronizes the human biological clock in the suprachiasmatic nuclei of the hypothalamus to the solar 24-hour cycle. Short wavelengths, perceived as blue color, are the strongest synchronizing agent for the circadian system that keeps most biological and psychological rhythms internally synchronized. Circadian rhythm is important for optimum function of organisms and circadian sleep-wake disruptions or chronic misalignment often may lead to psychiatric and neurodegenerative illness. The beneficial effect on circadian synchronization, sleep quality, mood, and cognitive performance depends not only on the light spectral composition but also on the timing of exposure and its intensity. Exposure to blue light during the day is important to suppress melatonin secretion, the hormone that is produced by the pineal gland and plays crucial role in circadian rhythm entrainment. While the exposure to blue is important for keeping organism's wellbeing, alertness, and cognitive performance during the day, chronic exposure to low-intensity blue light directly before bed-time, may have serious implications on sleep quality, circadian phase and cycle durations. This rises inevitably the need for solutions to improve wellbeing, alertness and cognitive performance in today's modern society where exposure to blue light emitting devices is ever increasing. This article is protected by copyright. All rights reserved. |
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Carl Zeiss Vision International GmbH, Aalen, Germany |
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English |
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1864-063X |
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Notes |
PMID:31433569 |
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no |
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Call Number |
GFZ @ kyba @ |
Serial |
2655 |
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Author |
Franklin, M.; Yin, X.; McConnell, R.; Fruin, S. |
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Title |
Association of the Built Environment With Childhood Psychosocial Stress |
Type |
Journal Article |
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Year |
2020 |
Publication |
JAMA Network Open |
Abbreviated Journal |
JAMA Netw Open |
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Volume |
3 |
Issue |
10 |
Pages |
e2017634 |
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Keywords |
Human Health; Remote Sensing |
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Abstract |
Importance: Emerging research suggests that factors associated with the built environment, including artificial light, air pollution, and noise, may adversely affect children's mental health, while living near green space may reduce stress. Little is known about the combined roles of these factors on children's stress. Objective: To investigate associations between components of the built environment with personal and home characteristics in a large cohort of children who were assessed for perceived stress. Design, Setting, and Participants: In this cohort study, a total of 2290 Southern California Children's Health Study participants residing in 8 densely populated urban communities responded to detailed questionnaires. Exposures of artificial light at night (ALAN) derived from satellite observations, near-roadway air pollution (NRP) determined from a dispersion model, noise estimated from the US Traffic Noise Model, and green space from satellite observations of the enhanced vegetation index were linked to each participant's geocoded residence. Main Outcomes and Measures: Children's stress was assessed at ages 13 to 14 years and 15 to 16 years using the 4-item Perceived Stress Scale (PSS-4), scaled from 0 to 16, with higher scores indicating greater perceived stress. Measurements were conducted in 2010 and 2012, and data were analyzed from February 6 to August 24, 2019. Multivariate mixed-effects models were used to examine multiple exposures; modification and mediation analyses were also conducted. Results: Among the 2290 children in this study, 1149 were girls (50%); mean (SD) age was 13.5 (0.6) years. Girls had significantly higher perceived stress measured by PSS-4 (mean [SD] score, 5.7 [3.4]) than boys (4.9 [3.2]). With increasing age (from 13.5 [0.6] to 15.3 [0.6] years), the mean PSS-4 score rose from 5.6 (3.3) to 6.0 (3.4) in girls but decreased for boys from 5.0 (3.2) to 4.7 (3.1). Multivariate mixed-effects models examining multiple exposures indicated that exposure to secondhand smoke in the home was associated with a 0.85 (95% CI, 0.46-1.24) increase in the PSS-4 score. Of the factors related to the physical environment, an interquartile range (IQR) increase in ALAN was associated with a 0.57 (95% CI, 0.05-1.09) unit increase in the PSS-4 score together with a 0.16 score increase per IQR increase of near-roadway air pollution (95% CI, 0.02-0.30) and a -0.24 score decrease per IQR increase of the enhanced vegetation index (95% CI, -0.45 to -0.04). Income modified the ALAN effect size estimate; participants in households earning less than $48000 per year had significantly greater stress per IQR increase in ALAN. Sleep duration partially mediated the associations between stress and both enhanced vegetation index (17%) and ALAN (18%). Conclusions and Relevance: In this cohort study, children's exposure to smoke at home in addition to residential exposure to ALAN and near-roadway air pollution were associated with increased perceived stress among young adolescent children. These associations appeared to be partially mitigated by more residential green space. The findings may support the promotion of increased residential green spaces to reduce pollution associated with the built environment, with possible mental health benefits for children. |
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Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles |
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English |
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ISSN |
2574-3805 |
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PMID:33084897 |
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Call Number |
GFZ @ kyba @ |
Serial |
3182 |
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