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Benot, S.; R. Goberna; R. J. Reiter; S. Garcia-Mauriño; C. Osuna; J. M. Guerrero |
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Title |
Physiological levels of melatonin contribute to the antioxidant capacity of human serum |
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Journal Article |
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1999 |
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Journal of Pineal Research |
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27 |
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59-64 |
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Human Health |
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This work evaluates whether physiological concentrations of the pineal secretory product melatonin contribute to the total antioxidant status (TAS) of human serum. Day and nighttime serum samples were collected from healthy volunteers ranging from 2 to 89 years of age and used to measure melatonin and TAS. Results showed that both melatonin and TAS in human serum exhibited 24 hr variations with nocturnal peak values at 01:00 hr. Moreover, exposure of volunteers to light at night resulted in clear decreases of both TAS and melatonin. Furthermore, when melatonin was removed from sera collected at night, the TAS value of the sample was reduced to basal daytime values. In aging studies, it was found that nocturnal serum values of TAS and melatonin exhibited maximal values during the first four decades; thereafter, these values decreased as age advanced. In 60-year-old individuals, day/night differences in serum melatonin and TAS levels were clearly diminished, by more than 80%, with these differences being completely abolished in older individuals. Our results suggest that melatonin contributes to the total antioxidative capability of human serum. This antioxidant contribution of melatonin is reduced as age advances correlating with the age-related reduction of melatonin. |
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LoNNe @ kagoburian @ |
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719 |
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Davis, R. L. |
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Title |
Light Exposure and Breast Cancer |
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Journal Article |
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Year |
1991 |
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Epidemiology |
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2 |
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6 |
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458 |
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Human Health |
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735 |
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Gall, D. |
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Title |
Die Messung circadianer Strahlungsgrößen |
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2004 |
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Technische Universität Illmenau |
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17 |
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Human Health |
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754 |
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Immelmann, K.; K. R. Scherer; C. Vogel; P. Schmoock, |
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Psychobiologie. Grundlagen des Verhaltens |
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1988 |
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Psychobiologie. Grundlagen des Verhaltens |
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888 |
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Human Health; Animals |
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765 |
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Kretschmer, V.; B. Griefahn; K. H. Schmidt , |
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Title |
Light-Induced Adaptation to Night Work: Effects on Cognitive Performance in Elderly Persons |
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2011 |
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Journal of Psychophysiology |
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25 |
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1 |
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LoNNe @ kagoburian @ |
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773 |
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