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Author Walker, W.H. 2nd; Melendez-Fernandez, O.H.; Nelson, R.J. url  doi
openurl 
  Title Prior exposure to dim light at night impairs dermal wound healing in female C57BL/6 mice Type Journal Article
  Year 2019 Publication Archives of Dermatological Research Abbreviated Journal Arch Dermatol Res  
  Volume 311 Issue 7 Pages 573-576  
  Keywords (up) Animals; mouse models; Skin; Human Health  
  Abstract Artificial light at night (LAN) is a pervasive phenomenon in today's society, and the detrimental consequences of LAN exposure are becoming apparent. LAN is associated with the increased incidence of metabolic disorders, cancers, mood alterations, and immune dysfunction in mammals. Consequently, we examined the effects of dim LAN (DLAN) on wound healing. Female C57BL/6 mice were housed for 3 weeks in DLAN or LD conditions prior to wounding. Following wounding, mice were maintained in either their previous light conditions or switched to the opposite lighting conditions for 3 weeks. DLAN prior to wounding impaired healing; specifically, mice in DLAN/DLAN had significantly larger wounds on day 8. Additionally, mice in DLAN/LD had significantly larger wounds on days 5, 7, 8, and 9, and increased average time to closure. These data demonstrate a potential harmful effect of DLAN on wound healing that should be considered and may represent a target for therapeutic intervention.  
  Address Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, 26506, USA  
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  Series Volume Series Issue Edition  
  ISSN 0340-3696 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:31144020 Approved no  
  Call Number GFZ @ kyba @ Serial 2515  
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Author Kyba, C.C.M.; Aronson, K.J. url  doi
openurl 
  Title Assessing Exposure to Outdoor Lighting and Health Risks Type Journal Article
  Year 2015 Publication Epidemiology Abbreviated Journal Epidemiology  
  Volume 26 Issue 4 Pages e50  
  Keywords (up) Commentary, Human Health  
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  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1044-3983 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number LoNNe @ christopher.kyba @ Serial 1164  
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Author Burne, B.H. url  doi
openurl 
  Title Pollution By Light Type Journal Article
  Year 1972 Publication The Lancet Abbreviated Journal The Lancet  
  Volume 299 Issue 7751 Pages 642  
  Keywords (up) Commentary, Human Health  
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  Series Volume Series Issue Edition  
  ISSN 0140-6736 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number LoNNe @ christopher.kyba @ Serial 1191  
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Author LeGates, T.A.; Kvarta, M.D. url  doi
openurl 
  Title Illuminating a path from light to depression Type Journal Article
  Year 2020 Publication Nature Neuroscience Abbreviated Journal Nat Neurosci  
  Volume in press Issue Pages  
  Keywords (up) Commentary; Animals; Human Health  
  Abstract Our light environment can strongly influence our mental health. Kai An and colleagues dissect the neuronal circuit mediating depression-related behaviors induced by mistimed light input in mice, implicating the nucleus accumbens as the downstream target of the neural pathway between intrinsically photosensitive retinal ganglion cells and the perihabenular nucleus.  
  Address Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1097-6256 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:32555525 Approved no  
  Call Number GFZ @ kyba @ Serial 3015  
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Author Reiter, R.J.; Sharma, R.; Ma, Q. url  doi
openurl 
  Title Switching diseased cells from cytosolic aerobic glycolysis to mitochondrial oxidative phosphorylation: A metabolic rhythm regulated by melatonin? Type Journal Article
  Year 2021 Publication Journal of Pineal Research Abbreviated Journal J Pineal Res  
  Volume 70 Issue 1 Pages e12677  
  Keywords (up) Commentary; Animals; Human Health; Alzheimer disease; Warburg metabolism; cancer; circadian rhythm; fibrosis; mitochondria  
  Abstract This commentary reviews the concept of the circadian melatonin rhythm playing an essential role in reducing the development of diseases such as solid tumors which adopt cytosolic aerobic glycolysis (Warburg effect) to support their enhanced metabolism. Experimental data show that solid mammary tumors depend on aerobic glycolysis during the day but likely revert to mitochondrial oxidative phosphorylation at night for ATP production. This conversion of diseased cells during the day to a healthier phenotype at night occurs under control of the circulating melatonin rhythm. When the nocturnal melatonin rise is inhibited by light exposure at night, cancer cells function in the diseased state 24/7. The ability of melatonin to switch cancer cells as well as other diseased cells, for example, Alzheimer disease, fibrosis, hyperactivation of macrophages, etc, from aerobic glycolysis to mitochondrial oxidative phosphorylation may be a basic protective mechanism to reduce pathologies.  
  Address Department of Cell Systems and Anatomy, UT Health Science Center at San Antonio, San Antonio, TX, USA  
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  Language English Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN 0742-3098 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:32621295 Approved no  
  Call Number GFZ @ kyba @ Serial 3221  
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