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Author Leung, J.M.; Martinez, M.E. url  doi
openurl 
  Title Circadian Rhythms in Environmental Health Sciences Type Journal Article
  Year 2020 Publication Current Environmental Health Reports Abbreviated Journal Curr Environ Health Rep  
  Volume in press Issue Pages  
  Keywords Review; Human Health; Asthma; Biomarkers; Breast cancer; Circadian rhythms; DNA methylation; Environmental health  
  Abstract PURPOSE OF REVIEW: This review aims to explore how circadian rhythms influence disease susceptibility and potentially modify the effect of environmental exposures. We aimed to identify biomarkers commonly used in environmental health research that have also been the subject of chronobiology studies, in order to review circadian rhythms of relevance to environmental health and determine if time-of-day is an important factor to consider in environmental health studies. Moreover, we discuss opportunities for studying how environmental exposures may interact with circadian rhythms to structure disease pathology and etiology. RECENT FINDINGS: In recent years, the study of circadian rhythms in mammals has flourished. Animal models revealed that all body tissues have circadian rhythms. In humans, circadian rhythms were also shown to exist at multiple levels of organization: molecular, cellular, and physiological processes, including responding to oxidative stress, cell trafficking, and sex hormone production, respectively. Together, these rhythms are an essential component of human physiology and can shape an individual's susceptibility and response to disease. Circadian rhythms are relatively unexplored in environmental health research. However, circadian clocks control many physiological and behavioral processes that impact exposure pathways and disease systems. We believe this review will motivate new studies of (i) the impact of exposures on circadian rhythms, (ii) how circadian rhythms modify the effect of environmental exposures, and (iii) how time-of-day impacts our ability to observe the body's response to exposure.  
  Address Department of Environmental Health Sciences, Columbia University, 630 West 168th Street, Room 16-421C, New York, NY, USA. mem2352@cumc.columbia.edu  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2196-5412 ISBN Medium  
  Area Expedition Conference  
  Notes (down) PMID:32662059 Approved no  
  Call Number GFZ @ kyba @ Serial 3055  
Permanent link to this record
 

 
Author Takemura, Y.; Ito, M.; Shimizu, Y.; Okano, K.; Okano, T. url  doi
openurl 
  Title Adaptive light: a lighting control method aligned with dark adaptation of human vision Type Journal Article
  Year 2020 Publication Scientific Reports Abbreviated Journal Sci Rep  
  Volume 10 Issue 1 Pages 11204  
  Keywords Human Health; Vision; Lighting  
  Abstract Light exposure before sleep causes a reduction in the quality and duration of sleep. In order to reduce these detrimental effects of light exposure, it is important to dim the light. However, dimming the light often causes inconvenience and can lower the quality of life (QOL). We therefore aimed to develop a lighting control method for use before going to bed, in which the illuminance of lights can be ramped down with less of a subjective feeling of changes in illuminance. We performed seven experiments in a double-blind, randomized crossover design. In each experiment, we compared two lighting conditions. We examined constant illuminance, linear dimming, and three monophasic and three biphasic exponential dimming, to explore the fast and slow increases in visibility that reflect the dark adaptation of cone and rod photoreceptors in the retina, respectively. Finally, we developed a biphasic exponential dimming method termed Adaptive Light 1.0. Adaptive Light 1.0 significantly prevented the misidentification seen in constant light and effectively suppressed perceptions of the illuminance change. This novel lighting method will help to develop new intelligent lighting instruments that reduce the negative effect of light on sleep and also lower energy consumption.  
  Address The Smart Life Science Institute, ACROSS, Waseda University, Tokyo, Japan. okano@waseda.jp  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2045-2322 ISBN Medium  
  Area Expedition Conference  
  Notes (down) PMID:32641723; PMCID:PMC7343865 Approved no  
  Call Number GFZ @ kyba @ Serial 3050  
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Author Paksarian, D.; Rudolph, K.E.; Stapp, E.K.; Dunster, G.P.; He, J.; Mennitt, D.; Hattar, S.; Casey, J.A.; James, P.; Merikangas, K.R. url  doi
openurl 
  Title Association of Outdoor Artificial Light at Night With Mental Disorders and Sleep Patterns Among US Adolescents Type Journal Article
  Year 2020 Publication JAMA Psychiatry Abbreviated Journal JAMA Psychiatry  
  Volume in press Issue Pages  
  Keywords Human Health; Remote Sensing  
  Abstract Importance: Indoor nighttime light exposure influences sleep and circadian rhythms and is known to affect mood-associated brain circuits in animals. However, little is known about the association between levels of nighttime outdoor light and sleep and mental health in the population, especially among adolescents. Objective: To estimate associations of outdoor artificial light at night (ALAN) with sleep patterns and past-year mental disorder among US adolescents. Design, Setting, and Participants: This population-based, cross-sectional study of US adolescents used the National Comorbidity Survey-Adolescent Supplement, a nationally representative cross-sectional survey conducted from February 2001 through January 2004. A probability sample of adolescents aged 13 to 18 years was included. Analyses were conducted between February 2019 and April 2020. Exposures: Levels of outdoor ALAN, measured by satellite, with means calculated within census block groups. ALAN values were transformed into units of radiance (nW/cm2/sr). Main Outcomes and Measures: Self-reported habitual sleep patterns (weeknight bedtime, weeknight sleep duration, weekend bedtime delay, and weekend oversleep) and past-year mood, anxiety, behavior, and substance use disorders, measured via an in-person structured diagnostic interview. Parent-reported information was included in behavior disorder diagnoses. Results: Among 10123 adolescents (4953 boys [51.3%]; mean [SE] age, 15.2 [0.06] years [weighted]; 6483 for behavior disorder outcomes), ALAN was positively associated with indicators of social disadvantage, such as racial/ethnic minority status (median [IQR] ALAN: white adolescents, 12.96 [30.51] nW/cm2/sr; Hispanic adolescents: 38.54 [47.84] nW/cm2/sr; non-Hispanic black adolescents: 37.39 [51.88] nW/cm2/sr; adolescents of other races/ethnicities: 30.94 [49.93] nW/cm2/sr; P < .001) and lower family income (median [IQR] ALAN by family income-to-poverty ratio </=1.5: 26.76 [52.48] nW/cm2/sr; >6: 21.46 [34.38] nW/cm2/sr; P = .005). After adjustment for several sociodemographic characteristics, as well as area-level population density and socioeconomic status, this study found that higher ALAN levels were associated with later weeknight bedtime, and those in the lowest quartile of ALAN reported the longest weeknight sleep duration. Those in the highest quartile of ALAN went to bed 29 (95% CI, 15-43) minutes later and reported 11 (95% CI, 19-2) fewer minutes of sleep than those in the lowest quartile. ALAN was also positively associated with prevalence of past-year mood and anxiety disorder: each median absolute deviation increase in ALAN was associated with 1.07 (95% CI, 1.00-1.14) times the odds of mood disorder and 1.10 (95% CI, 1.05-1.16) times the odds of anxiety disorder. Further analyses revealed associations with bipolar disorder (odds ratio [OR], 1.19 [95% CI, 1.05-1.35]), specific phobias (OR, 1.18 [95% CI, 1.11-1.26]), and major depressive disorder or dysthymia (OR, 1.07 [95% CI, 1.00-1.15]). Among adolescent girls, differences in weeknight bedtime by ALAN (third and fourth quartiles vs first quartile) were greater with increasing years since menarche (F3, 8.15; P < .001). Conclusions and Relevance: In this study, area-level outdoor ALAN was associated with less favorable sleep patterns and mood and anxiety disorder in adolescents. Future studies should elucidate whether interventions to reduce exposure to ALAN may positively affect mental and sleep health.  
  Address Genetic Epidemiology Research Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, Maryland  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2168-622X ISBN Medium  
  Area Expedition Conference  
  Notes (down) PMID:32639562 Approved no  
  Call Number GFZ @ kyba @ Serial 3034  
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Author Garcia-Saenz, A.; Sanchez de Miguel, A.; Espinosa, A.; Costas, L.; Aragones, N.; Tonne, C.; Moreno, V.; Perez-Gomez, B.; Valentin, A.; Pollan, M.; Castano-Vinyal, G.; Aube, M.; Kogevinas, M. url  doi
openurl 
  Title Association between outdoor light-at-night exposure and colorectal cancer in Spain (MCC-Spain study) Type Journal Article
  Year 2020 Publication Epidemiology (Cambridge, Mass.) Abbreviated Journal Epidemiology  
  Volume in press Issue Pages  
  Keywords Human Health; Remote Sensing  
  Abstract BACKGROUND: Night shift work, exposure to artificial light-at-night and particularly blue light spectrum, and the consequent circadian disruption may increase the risk of breast and prostate cancer. Colorectal cancer risk may also be increased among night-shift workers. We investigated the association between exposure to artificial light at night according to light spectrum and colorectal cancer among subjects who had never worked at night in a general population case-control study in Spain. METHODS: We examined information on 661 incident histologically verified colorectal cancer cases and 1322 controls from Barcelona and Madrid, 2007-2013. Outdoor artificial light at night exposure was based on images from the International Space Station (ISS) including data on remotely sensed upward light intensity. We derived adjusted odds ratio (OR) estimates and confidence intervals (CI) for visual light, blue light, and spectral sensitivities of the five human photopigments assigned to participant's geocoded longest residence. RESULTS: : Exposure to blue light spectrum was positively associated with colorectal cancer (OR=1.6; 95%CI: 1.2-2.2; highest vs. lowest tertile). ORs were similar (OR=1.7; 95%CI: 1.3-2.3) when further adjusting for area socioeconomic status, diet patterns, smoking, sleep and family history. We observed no association for outdoor visual light (full spectrum) (OR = 1.0, 95%CI 0.7-1.2; highest vs. lowest tertile). Analysis of the five photopigments gave similar results with increased risks for shorter wavelengths overlapping with the blue spectrum and no association for longer wavelengths. CONCLUSIONS: Outdoor blue light spectrum exposure that is increasingly prevalent in recent years may be associated with colorectal cancer risk.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1044-3983 ISBN Medium  
  Area Expedition Conference  
  Notes (down) PMID:32639250 Approved no  
  Call Number GFZ @ kyba @ Serial 3043  
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Author Zhang, D.; Jones, R.R.; Powell-Wiley, T.M.; Jia, P.; James, P.; Xiao, Q. url  doi
openurl 
  Title A large prospective investigation of outdoor light at night and obesity in the NIH-AARP Diet and Health Study Type Journal Article
  Year 2020 Publication Environmental Health : a Global Access Science Source Abbreviated Journal Environ Health  
  Volume 19 Issue 1 Pages 74  
  Keywords Human Health; Remote Sensing; Circadian rhythms; Light at night; Light pollution; Obesity  
  Abstract BACKGROUND: Research has suggested that artificial light at night (LAN) may disrupt circadian rhythms, sleep, and contribute to the development of obesity. However, almost all previous studies are cross-sectional, thus, there is a need for prospective investigations of the association between LAN and obesity risk. The goal of our current study was to examine the association between baseline LAN and the development of obesity over follow-up in a large cohort of American adults. METHODS: The study included a sample of 239,781 men and women (aged 50-71) from the NIH-AARP Diet and Health Study who were not obese at baseline (1995-1996). We used multiple logistic regression to examine whether LAN at baseline was associated with the odds of developing obesity at follow-up (2004-2006). Outdoor LAN exposure was estimated from satellite imagery and obesity was measured based on self-reported weight and height. RESULTS: We found that higher outdoor LAN at baseline was associated with higher odds of developing obesity over 10 years. Compared with the lowest quintile of LAN, the highest quintile was associated with 12% and 19% higher odds of developing obesity at follow-up in men (OR (95% CI) = 1.12 (1.00, 1.250)) and women (1.19 (1.04, 1.36)), respectively. CONCLUSIONS: Our findings suggest that high LAN exposure could predict a higher risk of developing obesity in middle-to-older aged American adults.  
  Address Department of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1476-069X ISBN Medium  
  Area Expedition Conference  
  Notes (down) PMID:32611430; PMCID:PMC7329409 Approved no  
  Call Number GFZ @ kyba @ Serial 3029  
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