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Author Bashiri, F.; Hassan, C.R.C. doi  openurl
  Title Light Pollution and Its Effect on the Environment Type Journal Article
  Year 2014 Publication International Journal of Fundamental Physical Sciences Abbreviated Journal Intl. J. of Fundamental Phys. Sci.  
  Volume 4 Issue 1 Pages 8-12  
  Keywords Light pollution, human health, animal behaviour, plant growth  
  Abstract Light pollution can cause disturbance to humans as well as animals. The aim of this study is to determine the effect of light pollution on human's health, plants, animals, human body and People’s attitude about light pollution. About 90% of people strongly agreed that excessive lighting has adverse effects on a person's health. At least, 70% of people had difficulty in sleeping because of light pollution. Most of people believed that video Billboards, Spotlights, Car headlights and Street lights are the most important source of light pollution and about 60% of people agree that light pollution can affect animal’s sleep. 60% of people believed that excessive artificial light can attract several kinks of birds and insects. The results of this study indicate that the human health, plants growth and animal behaviour are strongly affected by the light pollution.‎  
  Address Faculty of Engineering University of Malaya, Kuala Lumpur, Malaysia  
  Corporate Author Thesis  
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  Notes Approved no  
  Call Number IDA @ john @ Serial 313  
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Author Fonken, L.K.; Nelson, R.J. url  doi
openurl 
  Title The Effects of Light at Night on Circadian Clocks and Metabolism Type Book Chapter
  Year 2014 Publication Endocrine Reviews Abbreviated Journal Endocr Rev  
  Volume 35 Issue 4 Pages 648-670  
  Keywords Human Health; Circadian Rhythm; clock genes; epidemiology; light at night; review  
  Abstract Most organisms display endogenously produced approximately ~24 h fluctuations in physiology and behavior, termed circadian rhythms. Circadian rhythms are driven by a transcriptional-translational feedback loop that is hierarchically expressed throughout the brain and body, with the suprachiasmatic nucleus of the hypothalamus serving as the master circadian oscillator at the top of the hierarchy. Appropriate circadian regulation is important for many homeostatic functions including energy regulation. Multiple genes involved in nutrient metabolism display rhythmic oscillations and metabolically related hormones such as glucagon, insulin, ghrelin, leptin, and corticosterone are released in a circadian fashion. Mice harboring mutations in circadian clock genes alter feeding behavior, endocrine signaling, and dietary fat absorption. Moreover, misalignment between behavioral and molecular circadian clocks can result in obesity in both rodents and humans. Importantly, circadian rhythms are most potently synchronized to the external environment by light information and exposure to light at night potentially disrupts circadian system function. Since the advent of electric lights around the turn of the 20th century, exposure to artificial and irregular light schedules has become commonplace. The increase in exposure to light at night parallels the global increase in the prevalence of obesity and metabolic disorders. In this review, we propose that exposure to light at night alters metabolic function through disruption of the circadian system. We first provide an introduction to the circadian system, with a specific emphasis on the effects of light on circadian rhythms. Next we address interactions between the circadian system and metabolism. Finally, we review current experimental and epidemiological work directly associating exposure to light at night and metabolism.  
  Address Department of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, OH 43210 USA  
  Corporate Author Thesis  
  Publisher Endocrine Society Place of Publication Editor  
  Language English Summary Language Original Title (down)  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0163-769X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24673196 Approved no  
  Call Number IDA @ john @ Serial 314  
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Author Dauchy, R.T.; Xiang, S.; Mao, L.; Brimer, S.; Wren, M.A.; Yuan, L.; Anbalagan, M.; Hauch, A.; Frasch, T.; Rowan, B.G.; Blask, D.E.; Hill, S.M. url  doi
openurl 
  Title Circadian and melatonin disruption by exposure to light at night drives intrinsic resistance to tamoxifen therapy in breast cancer Type Journal Article
  Year 2014 Publication Cancer Research Abbreviated Journal Cancer Res  
  Volume 74 Issue 15 Pages 4099-4110  
  Keywords *Cancer; breast cancer; melatonin; endocrinology; tamoxifen; *Circadian Rhythm; circadian disruption; human health; epidemiology  
  Abstract Resistance to endocrine therapy is a major impediment to successful treatment of breast cancer. Preclinical and clinical evidence links resistance to antiestrogen drugs in breast cancer cells with the overexpression and/or activation of various pro-oncogenic tyrosine kinases. Disruption of circadian rhythms by night shift work or disturbed sleep-wake cycles may lead to an increased risk of breast cancer and other diseases. Moreover, light exposure at night (LEN) suppresses the nocturnal production of melatonin that inhibits breast cancer growth. In this study, we used a rat model of estrogen receptor (ERalpha(+)) MCF-7 tumor xenografts to demonstrate how altering light/dark cycles with dim LEN (dLEN) speed the development of breast tumors, increasing their metabolism and growth and conferring an intrinsic resistance to tamoxifen therapy. These characteristics were not observed in animals in which the circadian melatonin rhythm was not disrupted, or in animals subjected to dLEN if they received nocturnal melatonin replacement. Strikingly, our results also showed that melatonin acted both as a tumor metabolic inhibitor and a circadian-regulated kinase inhibitor to reestablish the sensitivity of breast tumors to tamoxifen and tumor regression. Together, our findings show how dLEN-mediated disturbances in nocturnal melatonin production can render tumors insensitive to tamoxifen. Cancer Res; 74(15); 4099-110. (c)2014 AACR.  
  Address Departments of Structural and Cellular Biology and Tulane Cancer Center and Louisiana Cancer Research Consortium; Tulane Circadian Cancer Biology Group; and  
  Corporate Author Thesis  
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  Language English Summary Language Original Title (down)  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0008-5472 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:25062775; PMCID:PMC4119539 Approved no  
  Call Number IDA @ john @ Serial 355  
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Author Figueiro, M.G.; Wood, B.; Plitnick, B.; Rea, M.S. url  doi
openurl 
  Title The impact of watching television on evening melatonin levels: Impact of watching television on evening melatonin Type Journal Article
  Year 2013 Publication Journal of the Society for Information Display Abbreviated Journal Jnl Soc Info Display  
  Volume 21 Issue 10 Pages 417-421  
  Keywords Human Health; television; correlated color temperature; sleep; melatonin levels; blue light; circadian disruption  
  Abstract Self-luminous electronic devices emit optical radiation at short wavelengths, close to the peak sensitivity of melatonin suppression. The present paper investigated if light from a 178-cm (70 in.) television suppressed melatonin. Results showed that light from televisions does not impact melatonin levels in the evening.  
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  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1071-0922 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number LoNNe @ christopher.kyba @ Serial 498  
Permanent link to this record
 

 
Author Czeisler, C.A. url  doi
openurl 
  Title Perspective: casting light on sleep deficiency Type Journal Article
  Year 2013 Publication Nature Abbreviated Journal Nature  
  Volume 497 Issue 7450 Pages S13  
  Keywords Human Health; Circadian Rhythm/physiology/radiation effects; Electricity/adverse effects; Humans; Jet Lag Syndrome/etiology/physiopathology/therapy; Lighting/*adverse effects; Melatonin/metabolism/secretion; Phototherapy; Sleep Deprivation/epidemiology/*etiology/*physiopathology/therapy; Suprachiasmatic Nucleus/physiology/radiation effects  
  Abstract  
  Address Division of Sleep Medicine, Harvard Medical School, and Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital, in Boston, Massachusetts, USA. charles_czeisler@hms.harvard.edu  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title (down)  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0028-0836 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23698501 Approved no  
  Call Number LoNNe @ christopher.kyba @ Serial 499  
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