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Author Khan, Z.A.; Yumnamcha, T.; Mondal, G.; Devi, S.D.; Rajiv, C.; Labala, R.K.; Sanjita Devi, H.; Chattoraj, A. url  doi
openurl 
  Title (up) Artificial Light at Night (ALAN): A Potential Anthropogenic Component for the COVID-19 and HCoVs Outbreak Type Journal Article
  Year 2020 Publication Frontiers in Endocrinology Abbreviated Journal Front Endocrinol (Lausanne)  
  Volume 11 Issue Pages 622  
  Keywords Animals; Human Health; Review; ALAN; Covid-19; HCoVs; bat; melatonin; sustainability  
  Abstract The origin of the coronavirus disease 2019 (COVID-19) pandemic is zoonotic. The circadian day-night is the rhythmic clue to organisms for their synchronized body functions. The “development for mankind” escalated the use of artificial light at night (ALAN). In this article, we tried to focus on the possible influence of this anthropogenic factor in human coronavirus (HCoV) outbreak. The relationship between the occurrences of coronavirus and the ascending curve of the night-light has also been delivered. The ALAN influences the physiology and behavior of bat, a known nocturnal natural reservoir of many Coronaviridae. The “threatened” and “endangered” status of the majority of bat species is mainly because of the destruction of their proper habit and habitat predominantly through artificial illumination. The stress exerted by ALAN leads to the impaired body functions, especially endocrine, immune, genomic integration, and overall rhythm features of different physiological variables and behaviors in nocturnal animals. Night-light disturbs “virus-host” synchronization and may lead to mutation in the genomic part of the virus and excessive virus shedding. We also proposed some future strategies to mitigate the repercussions of ALAN and for the protection of the living system in the earth as well.  
  Address Biological Rhythm Laboratory, Department of Animal Science, Kazi Nazrul University, Asansol, India  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1664-2392 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:33013700; PMCID:PMC7511708 Approved no  
  Call Number GFZ @ kyba @ Serial 3169  
Permanent link to this record
 

 
Author Zubidat, A.E.; Fares, B.; Fares, F.; Haim, A. url  doi
openurl 
  Title (up) Artificial Light at Night of Different Spectral Compositions Differentially Affects Tumor Growth in Mice: Interaction With Melatonin and Epigenetic Pathways Type Journal Article
  Year 2018 Publication Cancer Control : Journal of the Moffitt Cancer Center Abbreviated Journal Cancer Control  
  Volume 25 Issue 1 Pages 1073274818812908  
  Keywords Human Health; 6-Smt; Cfl; EE-halogen; GDM-levels; body mass; carbon; corticosterone; cosinor analysis; light at night; yellow-LED  
  Abstract Lighting technology is rapidly advancing toward shorter wavelength illuminations that offer energy-efficient properties. Along with this advantage, the increased use of such illuminations also poses some health challenges, particularly breast cancer progression. Here, we evaluated the effects of artificial light at night (ALAN) of 4 different spectral compositions (500-595 nm) at 350 Lux on melatonin suppression by measuring its urine metabolite 6-sulfatoxymelatonin, global DNA methylation, tumor growth, metastases formation, and urinary corticosterone levels in 4T1 breast cancer cell-inoculated female BALB/c mice. The results revealed an inverse dose-dependent relationship between wavelength and melatonin suppression. Short wavelength increased tumor growth, promoted lung metastases formation, and advanced DNA hypomethylation, while long wavelength lessened these effects. Melatonin treatment counteracted these effects and resulted in reduced cancer burden. The wavelength suppression threshold for melatonin-induced tumor growth was 500 nm. These results suggest that short wavelength increases cancer burden by inducing aberrant DNA methylation mediated by the suppression of melatonin. Additionally, melatonin suppression and global DNA methylation are suggested as promising biomarkers for early diagnosis and therapy of breast cancer. Finally, ALAN may manifest other physiological responses such as stress responses that may challenge the survival fitness of the animal under natural environments.  
  Address 1 The Israeli Center for Interdisciplinary Research in Chronobiology, University of Haifa, Haifa, Israel  
  Corporate Author Thesis  
  Publisher SAGE Place of Publication Editor  
  Language English Summary Language English Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1073-2748 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30477310; PMCID:PMC6259078 Approved no  
  Call Number IDA @ john @ Serial 2143  
Permanent link to this record
 

 
Author Haim, A.; Zubidat, A.E. url  doi
openurl 
  Title (up) Artificial light at night: melatonin as a mediator between the environment and epigenome Type Journal Article
  Year 2015 Publication Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences Abbreviated Journal Philos Trans R Soc Lond B Biol Sci  
  Volume 370 Issue Pages 20140121  
  Keywords Human Health; melatonin; epigenetic modifications; epigenetics; epigenome; light pollution; breast cancer; oncogenesis; tumorigenesis; biomarkers  
  Abstract The adverse effects of excessive use of artificial light at night (ALAN) are becoming increasingly evident and associated with several health problems including cancer. Results of epidemiological studies revealed that the increase in breast cancer incidents co-distribute with ALAN worldwide. There is compiling evidence that suggests that melatonin suppression is linked to ALAN-induced cancer risks, but the specific genetic mechanism linking environmental exposure and the development of disease is not well known. Here we propose a possible genetic link between environmental exposure and tumorigenesis processes. We discuss evidence related to the relationship between epigenetic remodelling and oncogene expression. In breast cancer, enhanced global hypomethylation is expected in oncogenes, whereas in tumour suppressor genes local hypermethylation is recognized in the promoter CpG chains. A putative mechanism of action involving epigenetic modifications mediated by pineal melatonin is discussed in relation to cancer prevalence. Taking into account that ALAN-induced epigenetic modifications are reversible, early detection of cancer development is of great significance in the treatment of the disease. Therefore, new biomarkers for circadian disruption need to be developed to prevent ALAN damage.  
  Address The Israeli Center for Interdisciplinary Research in Chronobiology, Department of Evolutionary and Environmental Biology, University of Haifa, Mount Carmel, Haifa 31905, Israel; ahaim@research.haifa.ac.il  
  Corporate Author Thesis  
  Publisher Royal Society Place of Publication Editor  
  Language English Summary Language English Original Title  
  Series Editor Series Title The biological impacts of artificial light at night: from molecules to communities Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number IDA @ john @ Serial 1119  
Permanent link to this record
 

 
Author Kumar, P.; Ashawat, M.S.; Pandit, V.; Sharma, D.K. url  doi
openurl 
  Title (up) Artificial Light Pollution at Night: A Risk for Normal Circadian Rhythm and Physiological Functions in Humans Type Journal Article
  Year 2019 Publication Current Environmental Engineering Abbreviated Journal Cee  
  Volume 6 Issue 2 Pages 111-125  
  Keywords Human Health; Review  
  Abstract From the past three to four decades, ecologists and scientists have exhaustively studied the effect of increased artificial light pollution at night on the ecological and physiological behavior of mammals. The Suprachiasmatic Nuclei (SCN) or master clock in the brain of mammals including humans synchronizes the physiological functions with the light: dark cycle. The prolongation of light period in the light: dark cycle disrupts the circadian rhythm of mammals causing several negative or modified physiological consequences. Changed physiological level of melatonin, an important endocrine hormone, had been identified as an important factor causing different consequences such as cancer, diabetes mellitus, metabolic disturbances, oxidative stress, and depression. The presence of artificial light at night is the demand of the era but thoughts must be given to the prevention of consequences due to artificial light pollution and ‘how much is needed’. The review paper discusses the effect of artificial light pollution on the biological clock of humans and associated negative physiological consequences. Further, the paper also briefly discusses the economics of light pollution and measures needed to prevent physiological disorders in humans.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2212-7178 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 2695  
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Author Jakubowski, P. url  doi
openurl 
  Title (up) Artificial light sources as light pollutant of humans melatonin suppression Type Journal Article
  Year 2019 Publication Photonics Letters of Poland Abbreviated Journal Photon.Lett.PL  
  Volume 11 Issue 3 Pages 78  
  Keywords Human Health  
  Abstract Blue light emitted by LEDs might influence thenatural biological rhythm of a human being, whichcan beconsidered as environment pollution.In this paper the effect of the latest commercially available LEDs on melatonin suppression index (MSI) was analyzed. The research was based on spectral power distributionof a given LED(SPD) and melatonin suppression functionin reference to melatonin suppression under daylight (illuminant D65). The resultsof calculations show astrong correlation between CCT and MSI;however,MSI factor might vary for different LEDs with the same CCT.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2080-2242 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 2693  
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