toggle visibility Search & Display Options

Select All    Deselect All
 |   | 
Details
   print
  Records Links (down)
Author Benedetto, M.M.; Contin, M.A. url  doi
openurl 
  Title Oxidative Stress in Retinal Degeneration Promoted by Constant LED Light Type Journal Article
  Year 2019 Publication Frontiers in Cellular Neuroscience Abbreviated Journal Front. Cell. Neurosci.  
  Volume 13 Issue Pages  
  Keywords Vision; Human Health  
  Abstract Light pollution by artificial light, might accelerate retinal diseases and circadian asynchrony. The excess of light exposure is a growing problem in societies, so studies on the consequences of long-term exposure to low levels of light are needed to determine the effects on vision. The possibility to understand the molecular mechanisms of light damage will contribute to the knowledge about visual disorders related to defects in the phototransduction. Several animal models have been used to study retinal degeneration (RD) by light; however, some important aspects remain to be established. Previously, we demonstrated that cool white treatment of 200 lux light-emitting diode (LED) induces retinal transformation with rods and cones cell death and significant changes in opsin expression in the inner nuclear layer (INL) and ganglion cell layer (GCL). Therefore, to further develop describing the molecular pathways of RD, we have examined here the oxidative stress and the fatty acid composition in rat retinas maintained at constant light. We demonstrated the existence of oxidative reactions after 5 days in outer nuclear layer (ONL), corresponding to classical photoreceptors; catalase (CAT) enzyme activity did not show significant differences in all times studied and the fatty acid study showed that docosahexaenoic acid decreased after 4 days. Remarkably, the docosahexaenoic acid diminution showed a correlation with the rise in stearic acid indicating a possible association between them. We assumed that the reduction in docosahexaenoic acid may be affected by the oxidative stress in photoreceptors outer segment which in turn affects the stearic acid composition with consequences in the membrane properties. All these miss-regulation affects the photoreceptor survival through unknown mechanisms involved. We consider that oxidative stress might be one of the pathways implicated in RD promoted by light.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1662-5102 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 2333  
Permanent link to this record
 

 
Author Choi, S. J., Park, H. R. & Joo, E. Y. url  doi
openurl 
  Title Effects of Light on Daytime Sleep in 12 Hours Night Shift Workers: A Field Study Type Journal Article
  Year 2019 Publication Korean Sleep Research Society Abbreviated Journal  
  Volume 16 Issue 1 Pages 26-35  
  Keywords Human Health; Sleep  
  Abstract Objectives: Night shift workers suffer from sleep and daytime disturbances due to circadian misalignment. To investigate the role of environmental light in daytime sleep following 12 h-night shift work. Methods: we enrolled 12 h-shift female nurses working at one university-affiliated hospital (n=10, mean age 26.6 years, shift work duration 3.8 years). This is a cross-over study to compare sleep between under light exposure (30 lux) and in the dark (<5 lux) following 12 h-night duty. Two sessions of experiments were underwent and the interval between sessions was about a month. Psychomotor vigilance test (PVT) had performed on awakening from sleep at each session and sleep-wake pattern had been monitored by actigraphy throughout the study period. Daytime sleep was also compared with night sleep of age-and gender matched daytime workers (n=10). Results: Sleep parameters and PVT scores were not different between two light conditions. Activities during sleep seemed to be more abundant under 30 lux condition than in the dark, which was not significant. Compared to night sleep, daytime sleep of shift workers was different in terms of rapid eye movement (REM) sleep. Three shift workers showed sleep onset REM sleep and first REM sleep period was the longest during daytime sleep. Conclusions: Unexpectedly, daytime sleep of 12 h night shift workers was well-maintained regardless of light exposure. Early occurrence of REM sleep and shorter sleep latency during daytime sleep suggest that shift workers meet with misalignment of circadian rhythm as well as increased homeostatic sleep pressure drive.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Korean Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number IDA @ intern @ Serial 2635  
Permanent link to this record
 

 
Author Lee, E.; Kim, M. url  doi
openurl 
  Title Light and Life at Night as Circadian Rhythm Disruptors Type Journal Article
  Year 2019 Publication Chronobiology in Medicine Abbreviated Journal  
  Volume 1 Issue 3 Pages 95-102  
  Keywords Review; Human Health  
  Abstract Light is an important entraining agent for endogenous circadian rhythms. Artificial light at night (ALAN) negatively influences the circadian system, inducing acute effects on sleep and cognition, as well as chronic endocrine-disrupting effects resulting in obesity, cardiovascular disease, diabetes, and cancer. Although shift workers may be exposed to extreme ALAN, its impact on their health is obscured by factors such as daylight exposure, meal and sleep scheduling, and physical and social behavior. Studies have revealed a significant increase in breast cancer in high ALAN-polluted areas, although the correlation with outdoor or indoor lighting conditions is controversial. Increasing use of electronic devices makes it difficult to assess ALAN exposure in the general population. The development of surrogate markers and critical parameters is crucial for health study by ALAN exposure, and such markers should include risk factors related to ALAN exposure. The present review considers articles investigating the risk of ALAN for shift workers, the general population, and users of electronic devices, and addresses susceptibility factors, including age, sex, and chronotype. Shift workers may be regarded as an extreme ALAN-exposure group, but the growing use of electronic devices and lifestyle changes in the general population make difficult to differentiate ALAN risks to health.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 2903  
Permanent link to this record
 

 
Author Park, H.R.; Choi, S.J.; Jo, H.; Cho, J.W.; Joo, E.Y. url  doi
openurl 
  Title Effects of Evening Exposure to Light from Organic Light-Emitting Diodes on Melatonin and Sleep Type Journal Article
  Year 2020 Publication Journal of Clinical Neurology Abbreviated Journal J Clin Neurol  
  Volume 16 Issue 3 Pages 401  
  Keywords Human Health  
  Abstract Background and Purpose

Organic light-emitting diodes (OLEDs) emit less blue light than traditional light-emitting diodes (LEDs), but the effects of OLED light exposure (LE) on melatonin and sleep have not been evaluated.

Methods

Twenty-four healthy subjects (age 26.9±5.7 years; including 18 females) with the intermediate chronotype were exposed to three different light conditions [4,000 K 150 lux OLED LE, 4,000 K 150 lux LED LE, and dim light (DL) at <10 lux] for 6.5 h from 17:30 to 24:00, in a random order and with a 1-week interval. Participants entered the unit for the experiment at 16:00, and their daylight was measured by actigraphy from 8:00 to 16:00 during each session. Saliva samples for melatonin were taken every hour from 18:00 to 24:00. Sleep was monitored by polysomnography, and vigilance was evaluated by psychomotor vigilance test upon awakening.

Results

Melatonin onset occurred at 21:11±01:24, 21:20±01:19, and 21:36±01:16 in the DL, OLED, and LED conditions, respectively. Melatonin onset was significantly delayed under LED LE compared to DL (p=0.007) but did not differ under OLED LE (p=0.245). Melatonin suppression, sleep parameters, and vigilance were similar among the three light conditions. The accumulated amount of daytime light in each session was negatively correlated with the melatonin onset time under the DL (rho=−0.634, p=0.002) and OLED (rho=−0.447, p=0.029) conditions, not under the LED condition (p=0.129).

Conclusions

Melatonin onset under OLED LE was not significantly delayed compared to DL. Exposure to sufficient daylight may advance melatonin onset even when a subject is exposed to OLED LE in the evening.
 
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1738-6586 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 3046  
Permanent link to this record
 

 
Author Pushkala, K., Gupta, P. D., & Geetha, R. url  openurl
  Title Differential Drift in Menarcheal Age in Blind and Sighted Girls Type Journal Article
  Year 2018 Publication Gynaecology and Perinatology Abbreviated Journal  
  Volume 2 Issue 4 Pages 333-339  
  Keywords Human Health  
  Abstract Our survey data show that menarcheal age, both in sighted and blind girls has drifted towards younger years compared to 50 years back, however, in sighted girls it has gone further down compared to blind girls. In this paper we have explained the reasons, why it is so? For the comparison sake we were very careful to select sighted and blind girls from the same geographical region, socio-economical and education status and food habits. Taking into consideration, our earlier hypothesis, “blind women and breast cancer”, here also we propose that only the photo regulatory system for hormonal axis is responsible for differential lowering of Menarcheal age in sighted and blind girls, since all other regulatory factors are same in both the groups.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number IDA @ intern @ Serial 2320  
Permanent link to this record
Select All    Deselect All
 |   | 
Details
   print

Save Citations:
Export Records: