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Author Stevens, R.G. url  openurl
  Title Electric power use and breast cancer: a hypothesis. Type Journal Article
  Year 1987 Publication Am J Epidemiol Abbreviated Journal  
  Volume 125 Issue Pages 556-561  
  Keywords Human Health  
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  Notes Approved no  
  Call Number LoNNe @ christopher.kyba @ Serial 533  
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Author Sedgwick, W.T.; Schneider JR., F. url  doi
openurl 
  Title The Relation Of Illuminating Gas To Public Health Type Journal Article
  Year 1911 Publication Journal of the American Public Health Association Abbreviated Journal J Am Public Health Assoc  
  Volume 1 Issue 5 Pages 385-390  
  Keywords Human Health; History  
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  ISSN 0273-1975 ISBN Medium  
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  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 2422  
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Author Wu, J.; Dauchy, R.T.; Tirrell, P.C.; Wu, S.S.; Lynch, D.T.; Jitawatanarat, P.; Burrington, C.M.; Dauchy, E.M.; Blask, D.E.; Greene, M.W. url  doi
openurl 
  Title Light at Night Activates IGF-1R/PDK1 Signaling and Accelerates Tumor Growth in Human Breast Cancer Xenografts Type Journal Article
  Year 2011 Publication Cancer Research Abbreviated Journal Cancer Res  
  Volume 71 Issue 7 Pages 2622-2631  
  Keywords human health; mammals; Circadian Rhythm; nude rats  
  Abstract Regulation of diurnal and circadian rhythms and cell proliferation are coupled in all mammals, including humans. However, the molecular mechanisms by which diurnal and circadian rhythms regulate cell proliferation are relatively poorly understood. In this study, we report that tumor growth in nude rats bearing human steroid receptor-negative MCF-7 breast tumors can be significantly accelerated by exposing the rats to light at night (LAN). Under normal conditions of an alternating light/dark cycle, proliferating cell nuclear antigen (PCNA) levels in tumors were maximal in the early light phase but remained at very low levels throughout the daily 24-hour cycle period monitored. Surprisingly, PCNA was expressed in tumors continually at a high level throughout the entire 24-hour period in LAN-exposed nude rats. Daily fluctuations of Akt and mitogen activated protein kinase activation in tumors were also disrupted by LAN. These fluctuations did not track with PCNA changes, but we found that activation of the Akt stimulatory kinase phosphoinositide-dependent protein kinase 1 (PDK1) directly correlated with PCNA levels. Expression of insulin-like growth factor 1 receptor (IGF-1R), an upstream signaling molecule for PDK1, also correlated with fluctuations of PDK1/PCNA in the LAN group. In addition, circulating IGF-1 concentrations were elevated in LAN-exposed tumor-bearing nude rats. Finally, RNAi-mediated knockdown of PDK1 led to a reduction in PCNA expression and cell proliferation in vitro and tumor growth in vivo, indicating that PDK1 regulates breast cancer growth in a manner correlated with PCNA expression. Taken together, our findings demonstrate that LAN exposure can accelerate tumor growth in vivo, in part through continuous activation of IGF-1R/PDK1 signaling.  
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  Notes Approved no  
  Call Number LoNNe @ schroer @ Serial 1608  
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Author Kyba, C.C.M.; Aronson, K.J. url  doi
openurl 
  Title Assessing Exposure to Outdoor Lighting and Health Risks Type Journal Article
  Year 2015 Publication Epidemiology Abbreviated Journal Epidemiology  
  Volume 26 Issue 4 Pages e50  
  Keywords Commentary, Human Health  
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  Series Volume Series Issue Edition  
  ISSN 1044-3983 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number LoNNe @ christopher.kyba @ Serial 1164  
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Author Figueiro, M.G.; Wood, B.; Plitnick, B.; Rea, M.S. url  doi
openurl 
  Title The impact of watching television on evening melatonin levels: Impact of watching television on evening melatonin Type Journal Article
  Year 2013 Publication Journal of the Society for Information Display Abbreviated Journal Jnl Soc Info Display  
  Volume 21 Issue 10 Pages 417-421  
  Keywords Human Health; television; correlated color temperature; sleep; melatonin levels; blue light; circadian disruption  
  Abstract Self-luminous electronic devices emit optical radiation at short wavelengths, close to the peak sensitivity of melatonin suppression. The present paper investigated if light from a 178-cm (70 in.) television suppressed melatonin. Results showed that light from televisions does not impact melatonin levels in the evening.  
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  ISSN 1071-0922 ISBN Medium  
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  Notes Approved no  
  Call Number LoNNe @ christopher.kyba @ Serial 498  
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