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Author (up) Ball, L.J.; Palesh, O.; Kriegsfeld, L.J. url  doi
openurl 
  Title The Pathophysiologic Role of Disrupted Circadian and Neuroendocrine Rhythms in Breast Carcinogenesis Type Journal Article
  Year 2016 Publication Endocrine Reviews Abbreviated Journal Endocrine Reviews  
  Volume Issue Pages er.2015-1133  
  Keywords Human Health  
  Abstract Most physiological processes in the brain and body exhibit daily (circadian) rhythms coordinated by an endogenous master clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus that are essential for normal health and functioning. Exposure to sunlight during the day and darkness at night optimally entrains biological rhythms to promote homeostasis and human health. Unfortunately, a major consequence of the modern lifestyle is increased exposure to sun-free environments during the day and artificial lighting at night. Additionally, behavioral disruptions to circadian rhythms (i.e., repeated transmeridian flights, night or rotating shift work, or sleep disturbances) have a profound influence on health and have been linked to a number of pathological conditions, including endocrine-dependent cancers. Specifically, night shift work has been identified as a significant risk factor for breast cancer in industrialized countries. Several mechanisms have been proposed by which shift-work-induced circadian disruptions promote cancer. In this review, we examine the importance of the brain-body link through which circadian disruptions contribute to endocrine-dependent diseases, including breast carcinogenesis, by negatively impacting neuroendocrine and neuroimmune cells and consider preventive measures directed at maximizing circadian health.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0163-769X ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number LoNNe @ kyba @ Serial 1496  
Permanent link to this record
 

 
Author (up) Fonken, L.K.; Nelson, R.J. url  doi
openurl 
  Title The Effects of Light at Night on Circadian Clocks and Metabolism Type Book Chapter
  Year 2014 Publication Endocrine Reviews Abbreviated Journal Endocr Rev  
  Volume 35 Issue 4 Pages 648-670  
  Keywords Human Health; Circadian Rhythm; clock genes; epidemiology; light at night; review  
  Abstract Most organisms display endogenously produced approximately ~24 h fluctuations in physiology and behavior, termed circadian rhythms. Circadian rhythms are driven by a transcriptional-translational feedback loop that is hierarchically expressed throughout the brain and body, with the suprachiasmatic nucleus of the hypothalamus serving as the master circadian oscillator at the top of the hierarchy. Appropriate circadian regulation is important for many homeostatic functions including energy regulation. Multiple genes involved in nutrient metabolism display rhythmic oscillations and metabolically related hormones such as glucagon, insulin, ghrelin, leptin, and corticosterone are released in a circadian fashion. Mice harboring mutations in circadian clock genes alter feeding behavior, endocrine signaling, and dietary fat absorption. Moreover, misalignment between behavioral and molecular circadian clocks can result in obesity in both rodents and humans. Importantly, circadian rhythms are most potently synchronized to the external environment by light information and exposure to light at night potentially disrupts circadian system function. Since the advent of electric lights around the turn of the 20th century, exposure to artificial and irregular light schedules has become commonplace. The increase in exposure to light at night parallels the global increase in the prevalence of obesity and metabolic disorders. In this review, we propose that exposure to light at night alters metabolic function through disruption of the circadian system. We first provide an introduction to the circadian system, with a specific emphasis on the effects of light on circadian rhythms. Next we address interactions between the circadian system and metabolism. Finally, we review current experimental and epidemiological work directly associating exposure to light at night and metabolism.  
  Address Department of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, OH 43210 USA  
  Corporate Author Thesis  
  Publisher Endocrine Society Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0163-769X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24673196 Approved no  
  Call Number IDA @ john @ Serial 314  
Permanent link to this record
 

 
Author (up) Fonken, L.K.; Nelson, R.J. url  doi
openurl 
  Title The effects of light at night on circadian clocks and metabolism Type Journal Article
  Year 2014 Publication Endocrine Reviews Abbreviated Journal Endocr Rev  
  Volume 35 Issue 4 Pages 648-670  
  Keywords Animals  
  Abstract Most organisms display endogenously produced approximately 24-hour fluctuations in physiology and behavior, termed circadian rhythms. Circadian rhythms are driven by a transcriptional-translational feedback loop that is hierarchically expressed throughout the brain and body, with the suprachiasmatic nucleus of the hypothalamus serving as the master circadian oscillator at the top of the hierarchy. Appropriate circadian regulation is important for many homeostatic functions including energy regulation. Multiple genes involved in nutrient metabolism display rhythmic oscillations, and metabolically related hormones such as glucagon, insulin, ghrelin, leptin, and corticosterone are released in a circadian fashion. Mice harboring mutations in circadian clock genes alter feeding behavior, endocrine signaling, and dietary fat absorption. Moreover, misalignment between behavioral and molecular circadian clocks can result in obesity in both rodents and humans. Importantly, circadian rhythms are most potently synchronized to the external environment by light information and exposure to light at night potentially disrupts circadian system function. Since the advent of electric lights around the turn of the 20th century, exposure to artificial and irregular light schedules has become commonplace. The increase in exposure to light at night parallels the global increase in the prevalence of obesity and metabolic disorders. In this review, we propose that exposure to light at night alters metabolic function through disruption of the circadian system. We first provide an introduction to the circadian system, with a specific emphasis on the effects of light on circadian rhythms. Next we address interactions between the circadian system and metabolism. Finally, we review current experimental and epidemiological work directly associating exposure to light at night and metabolism.  
  Address Department of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0163-769X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24673196 Approved no  
  Call Number LoNNe @ kagoburian @ Serial 848  
Permanent link to this record
 

 
Author (up) Gerhart-Hines, Z.; Lazar, M.A. url  doi
openurl 
  Title Circadian Metabolism in the Light of Evolution Type Journal Article
  Year 2015 Publication Endocrine Reviews Abbreviated Journal Endocr Rev  
  Volume 36 Issue 3 Pages 289-304  
  Keywords Human Health, Animals  
  Abstract Circadian rhythm, or daily oscillation, of behaviors and biological processes is a fundamental feature of mammalian physiology that has developed over hundreds of thousands of years under the continuous evolutionary pressure of energy conservation and efficiency. Evolution has fine-tuned the body's clock to anticipate and respond to numerous environmental cues in order to maintain homeostatic balance and promote survival. However, we now live in a society in which these classic circadian entrainment stimuli have been dramatically altered from the conditions under which the clock machinery was originally set. A bombardment of artificial lighting, heating and cooling systems that maintain constant ambient temperature, sedentary lifestyle, and availability of inexpensive, high-calorie foods have threatened even the most powerful and ancient circadian programming mechanisms. Such environmental changes have contributed to the recent staggering elevation in lifestyle-influenced pathologies, including cancer, cardiovascular disease, depression, obesity and diabetes. This review scrutinizes the role of the body's internal clocks in the hard-wiring of circadian networks that have evolved to achieve energetic balance and adaptability, and discusses potential therapeutic strategies to reset clock metabolic control to modern time for the benefit of human health.  
  Address Section for Metabolic Receptology, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, 2200, DK  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0163-769X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:25927923 Approved no  
  Call Number LoNNe @ christopher.kyba @ Serial 1165  
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