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Author (up) Papantoniou, K.; Pozo, O.J.; Espinosa, A.; Marcos, J.; Castano-Vinyals, G.; Basagana, X.; Ribas, F.C.; Mirabent, J.; Martin, J.; Carenys, G.; Martin, C.R.; Middleton, B.; Skene, D.J.; Kogevinas, M. url  doi
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  Title Circadian variation of melatonin, light exposure, and diurnal preference in day and night shift workers of both sexes Type Journal Article
  Year 2014 Publication Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology Abbreviated Journal Cancer Epidemiol Biomarkers Prev  
  Volume 23 Issue 7 Pages 1176-1186  
  Keywords Human Health, physiology  
  Abstract BACKGROUND: Light-at-night has been shown in experimental studies to disrupt melatonin production but this has only partly been confirmed in studies of night shift workers. In this cross-sectional study, we examined the circadian variation of melatonin in relation to shift status, individual levels of light-at-night exposure, and diurnal preference, an attribute reflecting personal preference for activity in the morning or evening. METHODS: One hundred and seventeen workers (75 night and 42 day) of both sexes, ages 22 to 64 years, were recruited from four companies. Participants collected urine samples from all voids over 24 hours and wore a data logger continuously recording their light exposure. Sociodemographic, occupational, lifestyle, and diurnal preference information were collected by interview. Concentrations of urinary 6-sulfatoxymelatonin (aMT6s), the main melatonin metabolite, were measured. RESULTS: Mean aMT6s levels were lower in night [10.9 ng/mg creatinine/hour; 95% confidence interval (CI), 9.5-12.6] compared with day workers (15.4; 95% CI, 12.3-19.3). The lowest aMT6s levels were observed in night workers with morning preference (6.4; 95% CI, 3.0-13.6). Peak time of aMT6s production occurred 3 hours later in night (08:42 hour, 95% CI, 07:48-09:42) compared with day workers (05:36 hour, 95% CI, 05:06-06:12). Phase delay was stronger among subjects with higher light-at-night exposure and number of nights worked. CONCLUSIONS: Night shift workers had lower levels and a delay in peak time of aMT6s production over a 24-hour period. Differences were modified by diurnal preference and intensity of light-at-night exposure. IMPACT: Night shift work affects levels and timing of melatonin production and both parameters may relate to future cancer risk.  
  Address Authors' Affiliations: Centre for Research in Environmental Epidemiology (CREAL); IMIM (Hospital del Mar Medical Research Institute); Universitat Pompeu Fabra, Barcelona (UPF); CIBER Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain; National School of Public Health, Athens, Greece  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1055-9965 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24812038 Approved no  
  Call Number LoNNe @ christopher.kyba @ Serial 1111  
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