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Author (up) Gerhart-Hines, Z.; Lazar, M.A. url  doi
openurl 
  Title Circadian Metabolism in the Light of Evolution Type Journal Article
  Year 2015 Publication Endocrine Reviews Abbreviated Journal Endocr Rev  
  Volume 36 Issue 3 Pages 289-304  
  Keywords Human Health, Animals  
  Abstract Circadian rhythm, or daily oscillation, of behaviors and biological processes is a fundamental feature of mammalian physiology that has developed over hundreds of thousands of years under the continuous evolutionary pressure of energy conservation and efficiency. Evolution has fine-tuned the body's clock to anticipate and respond to numerous environmental cues in order to maintain homeostatic balance and promote survival. However, we now live in a society in which these classic circadian entrainment stimuli have been dramatically altered from the conditions under which the clock machinery was originally set. A bombardment of artificial lighting, heating and cooling systems that maintain constant ambient temperature, sedentary lifestyle, and availability of inexpensive, high-calorie foods have threatened even the most powerful and ancient circadian programming mechanisms. Such environmental changes have contributed to the recent staggering elevation in lifestyle-influenced pathologies, including cancer, cardiovascular disease, depression, obesity and diabetes. This review scrutinizes the role of the body's internal clocks in the hard-wiring of circadian networks that have evolved to achieve energetic balance and adaptability, and discusses potential therapeutic strategies to reset clock metabolic control to modern time for the benefit of human health.  
  Address Section for Metabolic Receptology, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, 2200, DK  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0163-769X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:25927923 Approved no  
  Call Number LoNNe @ christopher.kyba @ Serial 1165  
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