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Author (up) Coleman, G.; Gigg, J.; Canal, M.M. url  doi
  Title Postnatal light alters hypothalamic-pituitary-adrenal (HPA) axis function and induces a depressive-like phenotype in adult mice Type Journal Article
  Year 2016 Publication The European Journal of Neuroscience Abbreviated Journal Eur J Neurosci  
  Volume 44 Issue 10 Pages 2807-2817  
  Keywords Animals  
  Abstract The postnatal light environment that a mouse experiences during the critical first 3 postnatal weeks has long-term effects on both its circadian rhythm output and clock gene expression. Furthermore, data from our lab suggest that postnatal light may also impact the hypothalamic-pituitary-adrenal (HPA) axis, which is a key regulator of stress. To test the effect of postnatal light exposure on adult stress responses and circadian rhythmicity, we raised mice under either 24-h light-dark cycles (LD), constant light (LL) or constant dark (DD) during the first 3 postnatal weeks. After weaning we then exposed all animals to LD cycles (basal conditions), followed by LL (stressed conditions) environments. We examined brain neuropeptide and glucocorticoid receptor (GR) expression, plasma corticosterone concentration rhythm and body temperature rhythm, together with depression- and anxiety-related behaviour. Results showed that LL- and DD-raised mice exhibited decreased GR expression in the hippocampus, increased plasma corticosterone concentration at the onset of the dark phase and a depressive phenotype when exposed to LD cycles later in life. Furthermore, LL-raised mice showed increased corticotrophin-releasing hormone mRNA expression in the paraventricular nucleus of the hypothalamus. When exposed to LL as adults, LL-raised mice showed a significant circadian rhythm of plasma corticosterone concentration, together with a shorter period and stronger circadian rhythm of body temperature compared to DD-raised mice. Taken together, these data suggest that altered postnatal light environments have long-term effects on the HPA axis and the circadian system, which can lead to altered stress responses and a depressive phenotype in adulthood. This article is protected by copyright. All rights reserved.  
  Address Faculty of Life Sciences, University of Manchester, AV Hill Building, Oxford Road, M13 9PT, Manchester, UK.  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0953-816X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:27591429 Approved no  
  Call Number LoNNe @ kyba @ Serial 1523  
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