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Author Cho, E.; Oh, J.H.; Lee, E.; Do, Y.R.; Kim, E.Y.
Title Cycles of circadian illuminance are sufficient to entrain and maintain circadian locomotor rhythms in Drosophila Type Journal Article
Year 2016 Publication Scientific Reports Abbreviated Journal Sci Rep
Volume 6 Issue Pages 37784
Keywords Animals
Abstract Light at night disrupts the circadian clock and causes serious health problems in the modern world. Here, we show that newly developed four-package light-emitting diodes (LEDs) can provide harmless lighting at night. To quantify the effects of light on the circadian clock, we employed the concept of circadian illuminance (CIL). CIL represents the amount of light weighted toward the wavelengths to which the circadian clock is most sensitive, whereas visual illuminance (VIL) represents the total amount of visible light. Exposure to 12 h:12 h cycles of white LED light with high and low CIL values but a constant VIL value (conditions hereafter referred to as CH/CL) can entrain behavioral and molecular circadian rhythms in flies. Moreover, flies re-entrain to phase shift in the CH/CL cycle. Core-clock proteins are required for the rhythmic behaviors seen with this LED lighting scheme. Taken together, this study provides a guide for designing healthful white LED lights for use at night, and proposes the use of the CIL value for estimating the harmful effects of any light source on organismal health.
Address Neuroscience Graduate Program, BK21 Plus Program, Department of Biomedical Sciences, Ajou University School of Medicine, 164 Worldcup-ro, Suwon, 16499, Republic of Korea
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor (up) Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2045-2322 ISBN Medium
Area Expedition Conference
Notes PMID:27883065; PMCID:PMC5121609 Approved no
Call Number LoNNe @ kyba @ Serial 1565
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