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Author (up) Leung, L.; Grundy, A.; Siemiatycki, J.; Arseneau, J.; Gilbert, L.; Gotlieb, W.H.; Provencher, D.M.; Aronson, K.J.; Koushik, A. url  doi
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  Title Shift Work Patterns, Chronotype, and Epithelial Ovarian Cancer Risk Type Journal Article
  Year 2019 Publication Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology Abbreviated Journal Cancer Epidemiol Biomarkers Prev  
  Volume in press Issue Pages  
  Keywords Human Health  
  Abstract BACKGROUND: Shift work causing circadian disruption is classified as a 'probable carcinogen' and may contribute to the pathogenesis of hormone-sensitive cancers. This study investigated shift work exposure in relation to epithelial ovarian cancer (EOC) risk. METHODS: In a population-based case-control study with 496 EOC cases and 906 controls, lifetime occupational histories were collected and used to calculate cumulative years of shift work exposure, average number of night shifts per month, and average number of consecutive night shifts per month. Odds ratios (ORs) and 95% confidence intervals (CIs) for associations with EOC risk were estimated using logistic regression. Associations were also examined according to chronotype and menopausal status. RESULTS: Over half of the cases (53.4%) and controls (51.7%) worked evening and/or night shifts. There was no clear pattern of increasing EOC risk with increasing years of shift work; the adjusted OR (95%CI) of EOC comparing the highest shift work category vs. never working shift work was 1.20 (0.89-1.63). This association was more pronounced among those self-identified as having a “morning” chronotype (OR=1.64, 95%CI: 1.01-2.65). Associations did not greatly differ by menopausal status. CONCLUSION: These results do not strongly demonstrate a relationship between shift work and EOC risk. IMPACT: This study collected detailed shift work information and examined shift work patterns according to shift times and schedules. The findings highlight that chronotype should be considered in studies of shift work as an exposure.  
  Address Department of Social and Preventive Medicine, Universite de Montreal anita.koushik@umontreal.ca  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1055-9965 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30842128 Approved no  
  Call Number GFZ @ kyba @ Serial 2261  
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