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Author (up) Bedrosian, T.A.; Nelson, R.J. url  doi
openurl 
  Title Timing of light exposure affects mood and brain circuits Type Journal Article
  Year 2017 Publication Translational Psychiatry Abbreviated Journal Transl Psychiatry  
  Volume 7 Issue 1 Pages e1017  
  Keywords Review; Human Health  
  Abstract Temporal organization of physiology is critical for human health. In the past, humans experienced predictable periods of daily light and dark driven by the solar day, which allowed for entrainment of intrinsic circadian rhythms to the environmental light-dark cycles. Since the adoption of electric light, however, pervasive exposure to nighttime lighting has blurred the boundaries of day and night, making it more difficult to synchronize biological processes. Many systems are under circadian control, including sleep-wake behavior, hormone secretion, cellular function and gene expression. Circadian disruption by nighttime light perturbs those processes and is associated with increasing incidence of certain cancers, metabolic dysfunction and mood disorders. This review focuses on the role of artificial light at night in mood regulation, including mechanisms through which aberrant light exposure affects the brain. Converging evidence suggests that circadian disruption alters the function of brain regions involved in emotion and mood regulation. This occurs through direct neural input from the clock or indirect effects, including altered neuroplasticity, neurotransmission and clock gene expression. Recently, the aberrant light exposure has been recognized for its health effects. This review summarizes the evidence linking aberrant light exposure to mood.  
  Address Department of Neuroscience, Behavioral Neuroendocrinology Group, The Ohio State University Wexner Medical Center, Columbus, OH, USA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2158-3188 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28140399; PMCID:PMC5299389 Approved no  
  Call Number GFZ @ kyba @ Serial 2446  
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