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Author (up) Hsu, C.-N.; Tain, Y.-L. url  doi
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  Title Light and Circadian Signaling Pathway in Pregnancy: Programming of Adult Health and Disease Type Journal Article
  Year 2020 Publication International Journal of Molecular Sciences Abbreviated Journal Int J Mol Sci  
  Volume 21 Issue 6 Pages  
  Keywords Review; Human Health; circadian rhythm; developmental origins of health and disease (DOHaD); developmental programming; glucocorticoid; hypertension; light; melatonin; pregnancy  
  Abstract Light is a crucial environmental signal that affects elements of human health, including the entrainment of circadian rhythms. A suboptimal environment during pregnancy can increase the risk of offspring developing a wide range of chronic diseases in later life. Circadian rhythm disruption in pregnant women may have deleterious consequences for their progeny. In the modern world, maternal chronodisruption can be caused by shift work, jet travel across time zones, mistimed eating, and excessive artificial light exposure at night. However, the impact of maternal chronodisruption on the developmental programming of various chronic diseases remains largely unknown. In this review, we outline the impact of light, the circadian clock, and circadian signaling pathways in pregnancy and fetal development. Additionally, we show how to induce maternal chronodisruption in animal models, examine emerging research demonstrating long-term negative implications for offspring health following maternal chronodisruption, and summarize current evidence related to light and circadian signaling pathway targeted therapies in pregnancy to prevent the development of chronic diseases in offspring.  
  Address Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1422-0067 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:32210175 Approved no  
  Call Number GFZ @ kyba @ Serial 2874  
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