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Author (up) Weil, Z.M.; Fonken, L.K.; Walker, W.H. 2nd; Bumgarner, J.R.; Liu, J.A.; Melendez-Fernandez, O.H.; Zhang, N.; DeVries, A.C.; Nelson, R.J. url  doi
  Title Dim Light at Night Exacerbates Stroke Outcome Type Journal Article
  Year 2020 Publication The European Journal of Neuroscience Abbreviated Journal Eur J Neurosci  
  Volume in press Issue Pages in press  
  Keywords Animals; Mcao; circadian rhythms; cytokines; light pollution; neuroinflammation; stroke  
  Abstract Circadian rhythms are endogenous biological cycles that synchronize physiology and behavior to promote optimal function. These ~24-hour internal rhythms are set to precisely 24 hours daily by exposure to the sun. However, the prevalence of night-time lighting has the potential to dysregulate these biological functions. Hospital patients may be particularly vulnerable to the consequences of light at night because of their compromised physiological state. A mouse model of stroke (middle cerebral artery occlusion; MCAO) was used to test the hypothesis that exposure to dim light at night impairs responses to a major insult. Stroke lesion size was substantially larger among animals housed in dLAN after reperfusion than animals maintained in dark nights. Mice housed in dLAN for three days after the stroke displayed increased post-stroke anxiety-like behavior. Overall, dLAN amplified pro-inflammatory pathways in the CNS, which may have exacerbated neuronal damage. Our results suggest that exposure to LAN is detrimental to stroke recovery.  
  Address Department of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University School of Medicine, Morgantown, WV, 26506, USA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0953-816X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:32691462 Approved no  
  Call Number GFZ @ kyba @ Serial 3089  
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