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Author (up) Rakshit, K.; Thomas, A.P.; Matveyenko, A.V. url  doi
  Title Does disruption of circadian rhythms contribute to beta-cell failure in type 2 diabetes? Type Journal Article
  Year 2014 Publication Current Diabetes Reports Abbreviated Journal Curr Diab Rep  
  Volume 14 Issue 4 Pages 474  
  Keywords *epidemiology; diabetes; Type 2 diabetes; beta cell; T2DM; artificial light; light exposure; circadian disruption  
  Abstract Type 2 diabetes mellitus (T2DM) is a complex metabolic disease characterized by the loss of beta-cell secretory function and mass. The pathophysiology of beta-cell failure in T2DM involves a complex interaction between genetic susceptibilities and environmental risk factors. One environmental condition that is gaining greater appreciation as a risk factor for T2DM is the disruption of circadian rhythms (eg, shift-work and sleep loss). In recent years, circadian disruption has become increasingly prevalent in modern societies and consistently shown to augment T2DM susceptibility (partly mediated through its effects on pancreatic beta-cells). Since beta-cell failure is essential for development of T2DM, we will review current work from epidemiologic, clinical, and animal studies designed to gain insights into the molecular and physiological mechanisms underlying the predisposition to beta-cell failure associated with circadian disruption. Elucidating the role of circadian clocks in regulating beta-cell health will add to our understanding of T2DM pathophysiology and may contribute to the development of novel therapeutic and preventative approaches.  
  Address Larry L. Hillblom Islet Research Center, Department of Medicine, Division of Endocrinology, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, California, 900A Weyburn Place, Los Angeles, CA, 90095, USA  
  Corporate Author Thesis  
  Publisher Springer Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1534-4827 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24532160; PMCID:PMC3988110 Approved no  
  Call Number IDA @ john @ Serial 320  
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