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Author (up) Schernhammer, E.S.; Schulmeister, K. url  doi
  Title Melatonin and cancer risk: does light at night compromise physiologic cancer protection by lowering serum melatonin levels? Type Journal Article
  Year 2004 Publication British Journal of Cancer Abbreviated Journal Br J Cancer  
  Volume 90 Issue 5 Pages 941-943  
  Keywords Human Health; Animals; Circadian Rhythm/*radiation effects; Humans; Light/*adverse effects; Melatonin/*blood; Neoplasms/blood/*etiology; Risk Factors  
  Abstract The suprachiasmatic nuclei in the hypothalamus, one of the most important physiological determinants of alertness and performance, drive a circadian pacemaker in mammals, with an intrinsic period averaging 24 h. Light is the primary stimulus to the disruption and resetting of this pacemaker, which is expressed in changing melatonin rhythms. Melatonin production in humans decreases when people are exposed to light at night. Since melatonin shows potential oncostatic action in a variety of tumours, it is possible that lowered serum melatonin levels caused by exposure to light at night enhance the general tumour development. Cancer is the second leading cause of death in industrialised countries like the United States, where a significant proportion of workers engage in shift work, making a hypothesised relation between light exposure at night and cancer risk relevant. Observational studies support an association between night work and cancer risk. We hypothesise that the potential primary culprit for this observed association is the lack of melatonin, a cancer-protective agent whose production is severely diminished in people exposed to light at night.  
  Address Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA.  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0007-0920 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:14997186; PMCID:PMC2409637 Approved no  
  Call Number LoNNe @ kagoburian @ Serial 805  
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