toggle visibility Search & Display Options

Select All    Deselect All
 |   | 
Details
   print
  Records Links
Author Papagiannakopoulos, T.; Bauer, M.R.; Davidson, S.M.; Heimann, M.; Subbaraj, L.; Bhutkar, A.; Bartlebaugh, J.; Vander Heiden, M.G.; Jacks, T. url  doi
openurl 
  Title Circadian Rhythm Disruption Promotes Lung Tumorigenesis Type Journal Article
  Year 2016 Publication Cell Metabolism Abbreviated Journal Cell Metab  
  Volume 24 Issue 2 Pages 324–331  
  Keywords Animals  
  Abstract Circadian rhythms are 24-hr oscillations that control a variety of biological processes in living systems, including two hallmarks of cancer, cell division and metabolism. Circadian rhythm disruption by shift work is associated with greater risk for cancer development and poor prognosis, suggesting a putative tumor-suppressive role for circadian rhythm homeostasis. Using a genetically engineered mouse model of lung adenocarcinoma, we have characterized the effects of circadian rhythm disruption on lung tumorigenesis. We demonstrate that both physiologic perturbation (jet lag) and genetic mutation of the central circadian clock components decreased survival and promoted lung tumor growth and progression. The core circadian genes Per2 and Bmal1 were shown to have cell-autonomous tumor-suppressive roles in transformation and lung tumor progression. Loss of the central clock components led to increased c-Myc expression, enhanced proliferation, and metabolic dysregulation. Our findings demonstrate that both systemic and somatic disruption of circadian rhythms contribute to cancer progression.  
  Address David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: tjacks@mit.edu  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language (up) Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1550-4131 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:27476975 Approved no  
  Call Number LoNNe @ kyba @ Serial 1497  
Permanent link to this record
 

 
Author Zoogman, P.; Liu, X.; Suleiman, R.M.; Pennington, W.F.; Flittner, D.E.; Al-Saadi, J.A.; Hilton, B.B.; Nicks, D.K.; Newchurch, M.J.; Carr, J.L.; Janz, S.J.; Andraschko, M.R.; Arola, A.; Baker, B.D.; Canova, B.P.; Chan Miller, C.; Cohen, R.C.; Davis, J.E.; Dussault, M.E.; Edwards, D.P.; Fishman, J.; Ghulam, A.; González Abad, G.; Grutter, M.; Herman, J.R.; Houck, J.; Jacob, D.J.; Joiner, J.; Kerridge, B.J.; Kim, J.; Krotkov, N.A.; Lamsal, L.; Li, C.; Lindfors, A.; Martin, R.V.; McElroy, C.T.; McLinden, C.; Natraj, V.; Neil, D.O.; Nowlan, C.R.; OSullivan, E.J.; Palmer, P.I.; Pierce, R.B.; Pippin, M.R.; Saiz-Lopez, A.; Spurr, R.J.D.; Szykman, J.J.; Torres, O.; Veefkind, J.P.; Veihelmann, B.; Wang, H.; Wang, J.; Chance, K. url  doi
openurl 
  Title Tropospheric emissions: Monitoring of pollution (TEMPO) Type Journal Article
  Year 2016 Publication Journal of Quantitative Spectroscopy and Radiative Transfer Abbreviated Journal Journal of Quantitative Spectroscopy and Radiative Transfer  
  Volume 186 Issue Pages 17-39  
  Keywords Instrumentation, Remote Sensing  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language (up) Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0022-4073 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number LoNNe @ kyba @ Serial 1498  
Permanent link to this record
 

 
Author Straka, T.M.; Lentini, P.E.; Lumsden, L.F.; Wintle, B.A.; van der Ree, R. url  doi
openurl 
  Title Urban bat communities are affected by wetland size, quality, and pollution levels Type Journal Article
  Year 2016 Publication Ecology and Evolution Abbreviated Journal Ecol Evol  
  Volume 6 Issue 14 Pages 4761-4774  
  Keywords Ecology, Animals  
  Abstract Wetlands support unique biota and provide important ecosystem services. These services are highly threatened due to the rate of loss and relative rarity of wetlands in most landscapes, an issue that is exacerbated in highly modified urban environments. Despite this, critical ecological knowledge is currently lacking for many wetland-dependent taxa, such as insectivorous bats, which can persist in urban areas if their habitats are managed appropriately. Here, we use a novel paired landscape approach to investigate the role of wetlands in urban bat conservation and examine local and landscape factors driving bat species richness and activity. We acoustically monitored bat activity at 58 urban wetlands and 35 nonwetland sites (ecologically similar sites without free-standing water) in the greater Melbourne area, southeastern Australia. We analyzed bat species richness and activity patterns using generalized linear mixed-effects models. We found that the presence of water in urban Melbourne was an important driver of bat species richness and activity at a landscape scale. Increasing distance to bushland and increasing levels of heavy metal pollution within the waterbody also negatively influenced bat richness and individual species activity. Areas with high levels of artificial night light had reduced bat species richness, and reduced activity for all species except those adapted to urban areas, such as the White-striped free-tailed bat (Austronomus australis). Increased surrounding tree cover and wetland size had a positive effect on bat species richness. Our findings indicate that wetlands form critical habitats for insectivorous bats in urban environments. Large, unlit, and unpolluted wetlands flanked by high tree cover in close proximity to bushland contribute most to the richness of the bat community. Our findings clarify the role of wetlands for insectivorous bats in urban areas and will also allow for the preservation, construction, and management of wetlands that maximize conservation outcomes for urban bats and possibly other wetland-dependent and nocturnal fauna.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language (up) Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2045-7758 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number LoNNe @ kyba @ Serial 1499  
Permanent link to this record
 

 
Author Plummer, K.E.; Hale, J.D.; O'Callaghan, M.J.; Sadler, J.P.; Siriwardena, G.M. url  doi
openurl 
  Title Investigating the impact of street lighting changes on garden moth communities Type Journal Article
  Year 2016 Publication Journal of Urban Ecology Abbreviated Journal J Urban Ecol  
  Volume 2 Issue 1 Pages juw004  
  Keywords Animals  
  Abstract Night time illumination of cities is undergoing radical change through the adoption of new street lighting technologies, but the impacts of these large-scale changes on biodiversity have not been explored. Moths are of particular concern because of their nocturnal ‘flight-to-light’ responses. Here we examine in situ effects of (1) street lamp replacement and (2) the spatial distribution of local street lighting on garden moth communities in Birmingham, UK, to determine whether current shifts in street lighting infrastructure are leading to an increased attraction of moths into suburban areas. Using a unique before-after-control-impact survey, we show that switching from narrow (low-pressure sodium) to broad spectrum (high-pressure sodium) lamps significantly increases the diversity of macro-moths in suburban gardens. Furthermore, we demonstrate the complex ways in which the moth community differentially responds to variation in street lighting characteristics. In particular we found that macro-moth attraction was greatest at high lamp densities, whilst micro-moth families responded more strongly to street lamp proximity and the density of UV-emitting lamps specifically. Our findings indicate that moths are attracted to suburban gardens with closer, more dense and more spectrally diverse local street lighting, and suggest that suburban areas could represent ecological traps for moth communities if they have insufficient resources to support moth survival and reproduction. Further research is now needed to determine whether street lighting is progressively damaging moth communities, and to understand whether these impacts could be mitigated through changes to street lighting regimes or through the provision of ecologically important habitats in urban landscapes.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language (up) Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2058-5543 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number LoNNe @ kyba @ Serial 1500  
Permanent link to this record
 

 
Author Farkas, A.; Szaz, D.; Egri, A.; Barta, A.; Meszaros, A.; Hegedus, R.; Horvath, G.; Kriska, G. url  doi
openurl 
  Title Mayflies are least attracted to vertical polarization: A polarotactic reaction helping to avoid unsuitable habitats Type Journal Article
  Year 2016 Publication Physiology & Behavior Abbreviated Journal Physiol Behav  
  Volume 163 Issue Pages 219-227  
  Keywords Animals  
  Abstract Like other aquatic insects, mayflies are positively polarotactic and locate water surfaces by means of the horizontal polarization of water-reflected light. However, may vertically polarized light also have implications for the swarming behaviour of mayflies? To answer this question, we studied in four field experiments the behavioural responses of Ephoron virgo and Caenis robusta mayflies to lamps emitting horizontally and vertically polarized and unpolarized light. In both species, unpolarized light induces positive phototaxis, horizontally polarized light elicits positive photo- and polarotaxis, horizontally polarized light is much more attractive than unpolarized light, and vertically polarized light is the least attractive if the stimulus intensities and spectra are the same. Vertically polarized light was the most attractive for C. robusta if its intensity was about two and five times higher than that of the unpolarized and horizontally polarized stimuli, respectively. We suggest that the mayfly behaviour observed in our experiments may facilitate the stability of swarming above water surfaces. Beside the open water surface reflecting horizontally polarized light, the shadow and mirror image of riparian vegetation at the edge of the water surface reflect weakly and non-horizontally (mainly vertically) polarized light. Due to their positive polarotaxis, flying mayflies remain continuously above the water surface, because they keep away from the unpolarized or non-horizontally polarizing edge regions (water surface and coast line) of water bodies. We also discuss how our findings can explain the regulation of mayfly colonization.  
  Address Danube Research Institute, MTA Centre for Ecological Research, H-1113 Budapest, Karolina ut 29-31, Hungary; Group for Methodology in Biology Teaching, Biological Institute, Eotvos University, H-1117 Budapest, Pazmany setany 1, Hungary. Electronic address: kriska@ludens.elte.hu  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language (up) Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0031-9384 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:27178399 Approved no  
  Call Number LoNNe @ kyba @ Serial 1501  
Permanent link to this record
Select All    Deselect All
 |   | 
Details
   print

Save Citations:
Export Records: